Oxidative stress in patients with chronic kidney disease

Not Applicable

Completed

• Conditions: Renal Chronic kidney disease, Cardiovascular disease; Urological and Genital Diseases; Chronic kidney disease

• Registration Number: ISRCTN31272864
• Lead Sponsor: HS Greater Glasgow and Clyde (UK)

Brief Summary

1. 2018 results in https://www.ncbi.nlm.nih.gov/pubmed/30094018 (added 22/01/2019)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-12-18
• Study Completion: 2015-02-01
• Last Update Posted: 11 February 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Aged over 18 years
2. Written informed consent
3. CKD - patients with chronic kidney disease recruited from local clinic. eGFR 15 - 30ml/min on recent bloods.
4. ESRD - patients with end stage renal disease recruited from local service. Currently receiving renal replacement therapy
5. HTN - patients with hypertension recruited from local clinic. Normal renal function but diagnosis of hypertension

Exclusion Criteria

1. Known liver disease (alcoholic liver disease, hepatitis, cirrhosis)
2. Known HIV infection
3. Known i.v. drug or alcohol abuse
4. Clinical signs of acute infection
5. Known pregnancy
6. Women of childbearing age are who are at risk of pregnancy
7. Subjects with a history of kidney stones
8. Subjects taking daily vitamin C supplements

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in flow mediated dilatation assessed by brachial artery ultrasound, after saline and after ascorbic acid

Secondary Outcome Measures

Name	Time	Method
<br> 1. Arterial stiffness assessed by pulse wave analysis using the Sphygmocor system.<br> 2. Biomarkers of oxidative stress both measured after saline and then at 0 and 60 minutes after ascorbic acid:<br> 2.1 Total antioxidant capacity measured by colorimetric assay<br> 2.2 Rate of reactive oxygen species generation measured by electron paramagnetic resonance<br>