A Randomized Study of the Efficacy and Safety of Neoadjuvant Therapy With BCD-217 (Nurulimab + Prolgolimab) Versus Standard Adjuvant Therapy With Pembrolizumab in Patients With Resectable Stage III Skin Melanoma.

Biocad36 个研究点分布在 2 个国家目标入组 411 人开始时间: 2023年4月5日最近更新: 2025年7月8日

适应症

干预措施

试验速览

阶段: 3 期
状态: 进行中（未招募）
发起方: Biocad
入组人数: 411
试验地点: 36
主要终点: event free survival (EFS)

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This study is an open-label, randomized, comparative phase III study, which will include subjects with resectable stage III skin melanoma (up to 3 resectable transient metastases are acceptable).

详细描述

In both study groups, adjuvant therapy is possible until melanoma progresses to unresectable stage III-IV, unacceptable toxicity, withdrawal of ICF or the end of the therapy period (12 months).

In case of postoperative relapse of the disease, at the decision of the investigator and if the lesion is resectable, radical surgical treatment can be carried out (R0 - resection) in accordance with current clinical guidelines without withdrawing the patient from the study.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Parallel
主要目的: Treatment
盲法: None

入排标准

年龄范围: 18 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Signed informed consent and the subject's ability to comply with the requirements of the clinical study protocol;
•Age ≥ 18 years at the time of signing the informed consent form;
•Histologically or cytologically confirmed (documented results of relevant studies are available) resectable stage IIIB/C/D skin melanoma;
•At least one clinically detectable lymph node accessible for biopsy and not more than three resectable in-transit metastases .
•Clinically detectable lymph nodes include:
•Palpable lymph nodes with pathologically confirmed melanoma
•Non-palpable but enlarged (≥15 mm in smallest diameter, RECIST 1.1) lymph nodes with pathologically confirmed melanoma
•Subject's consent to a biopsy;
•Consent to the evaluation of the PD-L1 status and BRAF V600 mutation status ;
•ECOG score 0-1;
•Life expectancy of at least 5 years;
•Willingness of subjects and their sexual partners of childbearing potential to use reliable methods of contraception from the date of signing the informed consent form throughout the study period and for 24 weeks after the administration of the last dose of the investigational therapy.

排除标准

•Ocular melanoma;
•Mucosal melanoma;
•Distant metastases;
•Impossibility of radical resection of the tumor, metastasis and/or involved lymph nodes;
•Presence of only in-transit transit/satellite metastases without confirmed involvement of lymph nodes;
•Prior therapy with checkpoint inhibitors (e.g. anti-CTLA-4 and/or anti-PD-1/PD-L1/PD-L2 products);
•Prior therapy with BRAF and MEK protein kinase inhibitors;
•Prior radiation therapy;
•Inability to determine BRAF status;
•Subjects with severe comorbidities, with life-threatening acute complications of the underlying disease at the time of signing the informed consent form;
•Current concomitant diseases at the time of screening, which increase the risk of severe adverse events during surgery and/or study therapy administration;
•stable angina, functional class III-IV;
•unstable angina or a history of myocardial infarction within less than 6 months prior to signing the informed consent form;
•moderate to severe cardiac failure (NYHA classes III and IV);
•uncontrolled hypertension (systolic blood pressure >150 mmHg or diastolic blood pressure >90 mmHg) ;
•a history of atopic asthma , angioneurotic edema;
•respiratory failure (moderate to severe), grade 3 or 4 chronic obstructive pulmonary disease;
•any other concomitant diseases (including, but not limited to, metabolic, hematological, renal, hepatic, pulmonary, neurological, endocrine, cardiac, infectious, gastrointestinal disorders), which expose the subject to an unacceptable risk during surgery or study therapy;
•Known or suspected systemic autoimmune diseases (including, but not limited to, systemic lupus erythematosus, Crohn's disease, ulcerative colitis (UC), systemic scleroderma, inflammatory myopathy, mixed connective tissue disease, overlap syndrome, etc.) ;
•A history of interstitial pulmonary disease or pneumonitis requiring systemic glucocorticoids;
•The need for glucocorticoid therapy (at >10mg/day prednisolone equivalent doses) or any other drugs with immunosuppressive effects within 6 months prior to randomization;
•Use of immunostimulants, monoclonal antibodies and/or colony-stimulating factors within less than 4 weeks prior to randomization in the study;
•Hematological abnormalities :
•neutrophils <1.5×109/L;
•platelets <100×109/L;
•hemoglobin <90 g/L;
•Renal impairment: creatinine ≥1.5×ULN;
•Hepatic impairment :
•Total bilirubin ≥1.3×ULN (except for subjects with Gilbert's syndrome, in whom bilirubin levels should not exceed 50 μmol/L);
•ALP, AST or ALT ≥1.5×ULN;
•Any surgery within less than 28 days prior to randomization in the study;
•History of oncological disease, except for radically treated diseases with remission for over 5 years prior randomization in this study ;
•Conditions limiting the subject's ability to comply with the Protocol requirements (in the Investigator's opinion );
•Participation in other clinical studies within less than 30 days prior to randomization and during this clinical study ;
•Acute infections or activation of chronic infectious diseases or systemic antibacterial therapy within less than 28 days prior to randomization;
•Active hepatitis B, active hepatitis C (confirmed by PCR), HIV-infection, currently or previously ;
•Impossibility to administer the investigational product intravenously;
•Impossibility to administer intravenous contrast agents (including due to hypersensitivity to contrast media);
•Hypersensitivity to any of the components of BCD-217, prolgolimab or pembrolizumab;
•A history of hypersensitivity to monoclonal antibody products;
•Pregnancy or breastfeeding.