Endovasculer Treatement of Male Pelvic Venous Insufficiency
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 主要终点
- semen analysis criteria
研究概览
简要总结
A varicocele is a collection of varicose veins within the pampiniform (spermatic) plexus secondary to reflux in the internal spermatic vein (ISV).The condition affects 10% to 15% of the general population but is detected in as many as 40% of men undergoing an infertility workup. Depending on the method used for diagnosis, varicoceles are reported as bilateral in 17% to 77% of men. Traditionally, the diagnosis was made through clinical examination; however,as with other venous reflux disorders, ultrasound has become the mainstay of diagnosis. The traditional indications for treatment include infertility in patients with appropriate semen abnormalities, chronic groin pain, testicular atrophy in adolescent varicoceles, and recurrent varicocele after previous repair. Other indications more recently described with variable strength of evidence include low serum testosterone (with or without erectile dysfunction), benign prostatic hypertrophy,enhancement of assisted fertility techniques, and recurrent first trimester pregnancy loss.Infertility affects 10% to 15% of men of reproductive age. In approximately 50%, a cause is not found. The proof that varicocele repair improves fertility remains elusive; however, there is general acceptance that treatment does improve abnormalities of semen production.The traditional measures to assess semen production are sperm motility,morphology, and total sperm count. However, sperm counts greatly vary from day to day in any individual patient, and these measures correlate poorly with infertility outcomes.
The investigators do this study to evaluate the effectiveness of endovascular therapy using coils and other sclerosing agents and compare their results with other traditonal surgical methods in treatement of varicocele.
详细描述
All included patients will undergo the following:
- History & examination
- Semen analysis preintervention.
- Scrotal duplex scan of testicular vessels and testicular size .
Technique:
- All interventions will be performed in the endovascular OR with set on C-ARM.
- Patient's position and comfort are issues that are important initially.
STEPS FOR SPERMATIC VENOGRAPHY AND VARICOCELE EMBOLIZATION
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years(Adult)
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Age between 18 to 40 years.
- •Grade three reflux by duplex ultrasound..
- •Recurrent varicocele after surgical treatement.
排除标准
- •Any contraindication for endovascular therapy regarding radiation or dye or sclerosing agents.
结局指标
主要结局
semen analysis criteria
时间窗: 3 month
sperm motility
semen analyis criteria
时间窗: 3 month
sperm number in milion/ml
次要结局
未报告次要终点
研究者
Ahmed Mohamed Abbas
principal investigator
Assiut University
