Myocardial Contrast Echocardiography in Congenital Heart Disease

Completed

• Conditions: Tetralogy of Fallot; D-Transposition of Great Arteries

• Registration Number: NCT00412685
• Lead Sponsor: Insel Gruppe AG, University Hospital Bern

Brief Summary

Patients with congenital heart disease in whom the right ventricle is exposed to pressure or volume overload show progressive systolic dysfunction of the right ventricle, the fact of which conveys substantial morbidity and mortality. The aim of this study is to investigate the myocardial perfusion in these patients by myocardial contrast echocardiography (MCE) in order to determine whether disturbed blood flow plays a role in the development of right ventricular systolic dysfunction.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-08
• Study First Submitted: 2006-12-15
• Study First Submitted QC: 2006-12-15
• Study First Posted: 2006-12-18
• Primary Completion: 2008-12
• Study Completion: 2008-12
• Status Verified: 2015-06
• Last Update Submitted: 2015-06-15
• Last Update Posted: 2015-06-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• D-TGA or Fallot-Tetralogy or Healthy person
• written informed consent
• Age >= 18 years

Exclusion Criteria

• Anaemia
• Pregnancy and breast feeding
• Diabetes mellitus
• Contraindications to stress testing (ergometry or adenosine)
• Known adverse reaction or hypersensitivity against V08DA (SonoVue) or its components or against adenosine

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

University Hospital Inselspital; 🇨🇭 Bern, Switzerland