The effect of atorvastatin plus aspirin versus placebo on the endothelial function and inflammation in HIV patients under antiretroviral treatment presenting a low risk of cardiovascular risk. A randomized and double blind clinical trial. - : The effect of atorvastatin with aspirin versus placebo.

Hospital das Clínicas da Universidade Federal de Pernambuco0 个研究点开始时间: 2015年9月1日最近更新: 2023年5月29日

适应症

试验速览

暂无简介。

•HIV patients on antiretroviral use ; both genders , aged between 18 and 60; lower cardiovascular risk than 10 % probability of occurrence of cardiovascular events in 10 years , as measured by the Framingham risk score .

•history of hospitalization and opportunistic infections in the past 90 days; history of chronic liver dysfunction, thyroid dysfunction, autoimmune disease, history of hepatitis B or C; pregnancy or breastfeeding; previous use of statins, fibrates, ezetemibe, omega 3 , aspirin, NSAIDs, oral anticoagulants, interferon, interleukins, growth hormones, immunoglobulins, glucocorticoids or other immunosuppressants; alcohol abuse; previous intolerance to statins and aspirin; hemophilia; AST and ALT greater or equal 120 IU / L; CPK grater ou equal 167 U / L; muscle trauma or recent surgery performed until four months earlier; history of cardiovascular disease, diabetes, cancer and renal dysfunction.

发起方

Hospital das Clínicas da Universidade Federal de Pernambuco