Health related quality of life in patients with chronic liver disease and effect of probiotics in the treatment of MHE and health related quality of life

Indian Council of Medical Research0 个研究点目标入组 120 人开始时间: 待定最近更新: 2021年11月24日

试验速览

暂无简介。

•All the patients with Chronic liver disease (CLD) aged between 15 to 80 years of both the genders would be enrolled consecutively. Selection criteria would be the following:
•1.All the consecutive patients diagnosed as CLD would be enrolled in the study. All these patients would be enrolled from the liver clinics of the department of gastroenterology and those admitted in the gastroenterology ward at AIIMS.
•2.Alcohol would be considered to be the cause of CLD, if the patient regularly consumed more than or equal to 80g/d of alcohol for five years
•3.The staging of cirrhosis would be done according to the Child Pugh classification: A, B and C
•4.The causes of CLD would be divided into:-
•a.viral hepatitis
•c.viral hepatitis combining with alcohol
•d.miscellaneous causes
•Part II: All the patients of both genders with MHE aged between 15 to 80 years of both the genders would be enrolled consecutively. Selection criteria would be the following:
•1.All the consecutive patients with CLD without overt encephalopathy would be screened for MHE and then recruited
•2.All these patients would be enrolled from the liver clinics and the gastroenterology ward, AIIMS
•3.The diagnosis of MHE would be based on abnormal psychometric tests (NCT-A and NCT-B or FCT-A and FCT-B) and /or abnormal P300 auditory event related potentials

•1. Patients with overt hepatic encephalopathy
•2. Active medical co-morbidities
•3. Malignancy
•4. Refused to participate in the study
•1.Presence of overt HE
•2.History of taking lactulose or probiotics or antibiotics, in the past 6 weeks.
•3.Presence of other neurological or psychiatric disorder
•4.Patients who underwent shunt surgery for portal hypertension
•5.History of taking medicines likely to interfere with psychometric performance
•6.History of alcohol intake during past 6 weeks
•7.History of GI hemorrhage or spontaneous bacterial peritonitis during the past 6 weeks
•8.Presence of significant co morbidities like CHD, chronic respiratory disease, chronic renal disease, malignancies, diabetes etc
•9.Presence of mature cataracts and diabetic retinopathy.

发起方