miRNA in Sweat, a Novel Digital Biomarker for Detection of Active Tuberculosis
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 主要终点
- Detection of miRNA (non-coding ribonucleic acid) in blood
研究概览
简要总结
The detection of miRNA (non-coding ribonucleic acid) in the blood in the context of active tuberculosis is an innovative approach to the detection of new disease-specific biomarkers.
The primary goal of this analysis is to define, for the first time, an miRNA fingerprint for tuberculosis in sweat. Samples that were collected as part of the Sweatb Study (NCT03667742) project are examined for the occurrence of disease-specific, non-coding miRNAs to define new biomarkers in the sweat. These biomarkers can be detected non-invasively and will help in the detection of patients with active tuberculosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients
- •Ability to understand the purpose of the study, provide signed and dated informed consent by patient or his/her legal representative
- •In-patients with acute tuberculosis, suspected tuberculosis or other pulmonary diseases (pneumonia, Bronchitis, COPD)
- •Inclusion criteria Healthy Donors:
- •negative for Quantiferon- TB Gold Plus Test or ELISpot
排除标准
- •Written rejection of the consent for the further use of the data
结局指标
主要结局
Detection of miRNA (non-coding ribonucleic acid) in blood
时间窗: Blood samples taken at baseline
Analysis of blood protein markers in patients with active tuberculosis
Detection of miRNA (non-coding ribonucleic acid) in sweat
时间窗: Sweat samples taken at baseline
Analysis of sweat protein markers in patients with active tuberculosis
次要结局
未报告次要终点