A Prospective Multicentre Cohort Study of Acute ST-segment Elevation Myocardial Infarction
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- ST Elevation Myocardial Infarction
- Sponsor
- Ruijin Hospital
- Enrollment
- 2000
- Locations
- 7
- Primary Endpoint
- MACE
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
ST-segment elevation myocardial infarction(STEMI) remains a major cause of morbidity and mortality worldwide, despite of the early reperfusion therapy, including fibrinolysis, primary percutaneous coronary intervention (PCI),and standardized medical treatment.To improve the prognosis of STEMI patients, the management in their hospitalization should be optimized, including improvements in risk stratification, more widespread use of an invasive strategy, implementation of care delivery systems prioritising immediate revascularisation through PCI (or fibrinolysis), advances in antiplatelet agents and anticoagulants, and greater use of secondary prevention strategies such as lipid-lowering therapy.
This study aims to standardized the management of STEMI patients and improve the prognosis of the STEMI patients.
Detailed Description
This study is a prospective cohort study. It aims to standardized the management of STEMI patients and improve the prognosis of the STEMI patients.
Investigators
RUIYAN ZHANG
Director of Cardiology Department, Chief Physician
Ruijin Hospital
Eligibility Criteria
Inclusion Criteria
- •ST elevation myocardial infarction
- •Coronary angiography and percutaneous coronary intervention within 12 hours of symptom onset
- •Capable and willing to provide informed conset and capable of completing study visits
Exclusion Criteria
- •Cardiovascular shock at admission
- •Severe physical disability
- •Active malignant tumors
- •Active autoimmune diseases
Outcomes
Primary Outcomes
MACE
Time Frame: 0-1 year
Major adverse cardiovascular events(MACE) in one year follow-up
Left Ventricular Function
Time Frame: 1 month, 6month and 1 year
Left ventricular end diastolic volume(LVEDV),Left ventricular end systolic volume(LVESE),Left ventricular ejection fraction(LVEF) changes within one year follow-up
Coronary angiography
Time Frame: 1 year
The pathological changes in culprit vessels in 1 year