Study Assessing the Efficacy and Safety of Alpelisib in combination with Nab-paclitaxel in Subjects With Advanced TNBC Who Carry Either a PIK3CA Mutation or Have PTEN Loss Without PIK3CA Mutatio
- Conditions
- Health Condition 1: C509- Malignant neoplasm of breast of unspecified siteHealth Condition 2: C499- Malignant neoplasm of connective and soft tissue, unspecified
- Registration Number
- CTRI/2020/09/027887
- Lead Sponsor
- ovartis Healthcare Pvt Ltd
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
1.Subject is � 18 years old at the time of informed consent
2.Subject has histologically confirmed diagnosis of advanced (loco-regionally recurrent and not amenable to curative therapy, or metastatic (stage IV)) TNBC
3.Subject has either a measurable disease per RECIST 1.1 criteria or, if no measurable disease is present, then at least one predominantly lytic bone lesion or mixed lytic-blastic bone lesion with identifiable soft tissue component (that can be evaluated by CT/MRI) must be present
Part B1: patients must have measurable disease
4.Subject has adequate tumor tissue to identify the PIK3CA mutation status (either carrying a mutation or without a mutation) and the PTEN loss status; both of which will determine whether the 5.subject can be allocated to Part A - PIK3CA mutation regardless of PTEN status; or to Part B - PTEN loss without a PIK3CA mutation
6.Subject has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
7.Subject has received no more than one line of therapy for metastatic disease.
8.Subject has adequate bone marrow and organ function
1.Subject has received prior treatment with any PI3K, mTOR or AKT inhibitor
2.Subject has a known hypersensitivity to alpelisib, nab-paclitaxel or to any of their excipients
3.Subject has not recovered from all toxicities related to prior anticancer therapies to NCI CTCAE version 4.03 Grade �1; with the exception of alopecia
4.Subject has central nervous system involvement
5.Subject with an established diagnosis of diabetes mellitus type I or uncontrolled type II based on Fasting Plasma Glucose and HbA1c
6.Subject has impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of the study drugs (e.g., ulcerative diseases, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, or small bowel resection) based on investigator discretion
7.Subject has a history of acute pancreatitis within 1 year of screening or past medical history of chronic pancreatitis
8.Subject has currently documented pneumonitis/interstitial lung disease
9.Subject has a history of severe cutaneous reactions, such as Steven-Johnson Syndrome (SJS), erythema multiforme (EM),Toxic Epidermal Necrolysis (TEN) or Drug Reaction with Eosinophilia and Systemic Syndrome (DRESS)
10.Subject with unresolved osteonecrosis of the jaw
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1-Progression-free Survival (PFS) Per Investigator Assessment in Study part A <br/ ><br>2-Progression-free Survival (PFS) Per Investigator Assessment in Study part B2 <br/ ><br>3-Overall Response Rate (ORR) based on local radiology assessments in subjects with measurable disease at baseline in study Part B1Timepoint: 1-Once approximately 192 PFS events in Study Part A had been observed, up to 35 months <br/ ><br>2-Time Frame: Once approximately 192 PFS events in Study Part B2 had been observed, up to 22 months <br/ ><br>3-Time Frame: Up to 6 months
- Secondary Outcome Measures
Name Time Method