aparoscopic liver resection (LLR) with low central venous pressure (CVP) by anaesthesiological CVP reduction vs. LLR without CVP reduction in elective hepatic resection – A Randomized Controlled Trial

Not Applicable

• Conditions: Patients with elective laparoscopic liver resection; C22; C78.7; D13.4; C22.1; Malignant neoplasm of liver and intrahepatic bile ducts; Secondary malignant neoplasm of liver and intrahepatic bile duct; Liver; Intrahepatic bile duct carcinoma

• Registration Number: DRKS00021748
• Lead Sponsor: niversitätsmedizin Mannheim - Chirurgische Klinik

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-06-17
• Study Completion: 2023-03-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Elective LLR
• Age equal or greater than 18 years
• Written informed consent

Exclusion Criteria

• Extrahepatic resection required based on preoperative imaging
• Expected lack of compliance
• Child B or C liver cirrhosis
• Atrial fibrillation (impossibility to validly measure CVP via central venous line)
• Impaired mental state or language problems

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Intraoperative blood loss [mL]

Secondary Outcome Measures

Name	Time	Method
• Blood loss during liver transection<br>• Number of patients requiring transfusions <br>• Operation time<br>• Conversion rate to open hepatic resections<br>• Transecetion time<br>• Need for additional inflow control <br>• Intraoperative complications <br>• Postoperative length of stay <br>• Biochemical blood value tests <br>• Resection margines<br>• Perioperative morbidity and mortality