Recurrent Campylobacter Bacteraemia in Immunocompromised Patients

Not yet recruiting

• Conditions: Campylobacter Infections
• Interventions: Other: Characteristics of patients and Campylobacter bacteraemia episodes

• Registration Number: NCT06432777
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Some rare cases of recurrent Campylobacter bacteraemia (RCB) exist with relapses months to years after an effective treatment and a negativation of all bacterial samples.

As of today, only around 20 cases have been described in the international literature for the last 30 years. The cases are likely highly underreported.

No study describes those recurrent Campylobacter bacteraemias at the scale of a country.

The aim of this multicentre, nationwide, retrospective study is to describe their precise epidemiology in France for the last 25 years, the immune profile of the patients, the specificities of the bacteria involved, the treatments received and the evolution of these infections.

The perspective is to propose a standardization of the medical care of those patients mainly by describing the effective treatments and the explorations of the immune system which should be considered.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-05
• Study First Submitted: 2024-05-14
• Study First Submitted QC: 2024-05-22
• Last Update Submitted: 2024-05-22
• Study First Posted: 2024-05-29
• Last Update Posted: 2024-05-29
• Study Start: 2024-06-01
• Primary Completion: 2025-05-01
• Study Completion: 2026-05-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• 2 episodes or more of Campylobacter bacteraemia separated by at least 60 days
• AND immunodeficiency condition
• followed by a French hospital

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Exclusion Criteria

-Opposition of the patient

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Recurrent Campylobacter bacteraemia	Characteristics of patients and Campylobacter bacteraemia episodes	Patients presenting at least two distinct episodes of Campylobacter bacteraemia separated by minimum 60 days and an immunodeficiency (innate or acquired) and followed by a French hospital

Primary Outcome Measures

Name	Time	Method
Description of the characteristics of the patients presenting with recurrent Campylobacter bacteraemia	Baseline	-characteristics of bacteraemia: clinical presentation, bacteria (species, antimicrobial susceptibility), secondary localizations, evolution, treatment modalities (antibiotics and immunother

Trial Locations

Locations (1)

Infectious diseases department, Hospital de la Croix Rousse,; 🇫🇷 Lyon, France