Study of Prognosis Value of Protein S100Beta and Copeptine in Seizure in the Emergency Department
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Seizures
- Sponsor
- Bistro Study Group
- Enrollment
- 300
- Locations
- 4
- Primary Endpoint
- Combined hospital admission, seizure recurrence, or death at day 7
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
We study the hypothesis that combination of Proteine S100 beta and Copeptin within normal ranges can rule out seizure recurrences and severe outcome, and allow early discharge from the emergency department
Detailed Description
Prospective study for a 12 month period in Paris (France) and London (UK). Inclusion criteria : * seizure within 24h of attendance to an Emergency department (ED) * or seizure in the ED Exclusion Criterie : * pregnancy * prisoneer Primary endpoint : - recurrence of seizure, hospitalisation more than 24 hours or death within seven days Secondary endpoint : * Hospital free days at day 7 and day 28 * Death, ICU admission, or neurosurgical intervention at day 7 and day 28 * Return visit to the ED or re admission at day 7 and day 28 data collection: * demographics * past medical history, medication * vital signs (Heart rate, temperature, Pulse oxymetry, blood pressure, GCS) on arrival * Pathology (White cell count, Sodium, Calcium, Glucose, lactate) * Protein S100B and Copeptin * Seizure characteristics (Witnessed, simple, partial, complex, provoked, acute symptomatic, idiopathic) * Discharge plan, outcomes Follow up at day 7 and day 28, hospital visit or phone call
Investigators
Yonathan Freund
Chef de Clinique - Research fellow. MD
Bistro Study Group
Eligibility Criteria
Inclusion Criteria
- •Seizure within 24 hours of ED attendance
- •Or Seizure in the ED
Exclusion Criteria
- •Pregnancy
- •age \< 18 years old
Outcomes
Primary Outcomes
Combined hospital admission, seizure recurrence, or death at day 7
Time Frame: 7 days
Secondary Outcomes
- Death or ICU admission(28 days)
- death or ICU admission(day 7)
- Hospital free days(day 28)
- Recurrence of seizure(7 days)