Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia

Phase 4

Completed

• Conditions: The effect of Nitrous Oxide on endothelial function for patients having elective surgery of 2 hour or more duration.; Other - Research that is not of generic health relevance and not applicable to specific health categories listed above

• Registration Number: ACTRN12605000555651
• Lead Sponsor: HMRC

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2005-09-29
• Study Completion: 2010-11-15
• Last Update Posted: 25 May 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 220

Inclusion Criteria

1. Any risk factors for arteriosclerosis (eg. hypertension, diabetes, age >60 yrs, coronary artery disease). 2. Planned general anaesthesia for surgery that includes a skin incision and expected to exceed two hours, and the patient is expected to be in hospital for at least three days.

Exclusion Criteria

1. Endoscopic or radiological procedures 2. Cardiac surgery3. Marked impairment of gas-exchange (requiring Fi02> 0.3)4. Thoracic surgery requiring one-lung ventilation (requiring Fi02> 0.3)5. Specific circumstances where N2O is contraindicated (eg. volvulus, pulmonary hypertension, raised intracranial pressure)6. Lack of provision of N2O.7. Patients considered to be at high-risk for PONV8. Patients considered to be at high-risk for wound infection.

Study & Design

• Study Type: Interventional
• Study Design: Not specified