Predicting Long-term Outcomes After Cardiac Arrest by Using Serum NGAL

Terminated

• Conditions: Out-of-Hospital Cardiac Arrest
• Interventions: Diagnostic Test: serum NGAL

• Registration Number: NCT03615300
• Lead Sponsor: Uijeongbu St. Mary Hospital

Brief Summary

This study was performed to determine the prognosis of patients after cardiac arrest using serum markers called NGAL. The initial NGAL values of patients with post-cardiac arrest syndrome are checked by blood tests, and the long-term neurological prognosis and survival rate are collected after 6 months.

Detailed Description

Serum NGAL is currently being used as a test to determine the likelihood of developing renal failure. However, in a previous study, serum NGAL correlated with neurological prognosis in post cardiac arrest syndrome patients. This prospective study attempts to see the role of serum NGAL as a prognostic factor by including a sufficient number of patients.

Study Timeline

• Study Start: 2018-06-28
• Study First Submitted: 2018-07-30
• Study First Submitted QC: 2018-08-02
• Study First Posted: 2018-08-03
• Primary Completion: 2022-05-01
• Study Completion: 2022-05-01
• Status Verified: 2024-05
• Last Update Submitted: 2024-05-09
• Last Update Posted: 2024-05-13

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 73

Inclusion Criteria

• Adult patients who underwent targeted temperature management after out-of-hospital cardiac arrest.

Exclusion Criteria

• Patients who did not survived 3 days after cardiac arrest.
• Pre-existing end-stage renal disease or dependence on renal replacement therapy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
poor neurologic outcome	serum NGAL	Patients with poor neurological prognosis after 6 months (CPC 3, 4, 5). serum NGAL is collected.
good neurologic outcome	serum NGAL	Patients with good neurological prognosis after 6 months (CPC 1, 2). serum NGAL is collected.

Primary Outcome Measures

Name	Time	Method
Long term neurologic outcome	6 months	Patients' CPC score after 6 months (good outcome : CPC score 1, 2 / poor outcome : CPC score 3, 4, 5)

Secondary Outcome Measures

Name	Time	Method
Proportion of participants with Overall Survival at 6 months	6 months	6-month survival rate of patients'

Trial Locations

Locations (1)

Uijeongbu St. Mary's Hospital; 🇰🇷 Uijeongbu-si, Gyeonggi-do, Korea, Republic of