Effect of oral furosemide on postpartum blood pressure in women with Hypertensive Disorders in Pregnancy: A Randomised Controlled Trial
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Prevalence of persistent hypertension 72 hours postpartum or at the time of discharge
研究概览
简要总结
Persistent postpartum hypertension is a significant cause of maternal morbidity including heart failure and stroke.While postpartum hypertension can present following a normotensive pregnancy most postpartum hypertension complications are in women with persistent hypertension following a pregnancy complicated by preeclampsia or Hypertensive disorder in pregnancy.in women with Hypertensive Disorder in pregnancy, blood pressure decreases in first 48hours postpartum and then increases during day 3to 6 postpartum as a result of fluid retention and mobilisation of large volume of sodium into intravascular compartment.This change in fluid dynamics can affect blood pressure and hinder efficient blood pressure control during postpartum.
Hypertensive Disorders in pregnancy include gestational hypertension preeclampsia and preeclampsia superimposed on chronic hypertension with or without severe features
Gestational hypertension is defined as 2BP more than 140/90 mmhg at least 4hours apart with no protein urea and no other laboratory abnormalities
Preeclampsia without severe features has additional requirement of proteinuria
Preeclampsia with severe features is diagnosed after 2 BP readings of more than 160/110 mmhg at least 4 hours apart or any of the abnormal lab parameters
Furosemide being loop diuretic acts on ascending loop of Henley in the kidneys to inhibit sodium and chloride absorption leading to increased urine output.This may be potential to reduce intravascular volume in postpartum period with fluid overload and assist with blood pressure control
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 45.00 Year(s)（—）
- 性别
- Female
入选标准
- •Women diagnosed with Hypertensive Disorder of pregnancy including gestational hypertension preeclampsia with or without severe features Hemodynamically stable patients who delivered a foetus of more than twenty week period of gestation.
排除标准
- •History of allergic reaction to furosemide Hypotension Hypokalaemia Women who received diuretics before randomisation High risk comorbidities for which treatment may be indicated like overt diabetes mellitus chronic kidney disease cardiac disorders of pregnancy.
结局指标
主要结局
Prevalence of persistent hypertension 72 hours postpartum or at the time of discharge
时间窗: 72hours postpartum
次要结局
- Percentage of postpartum BP in severe range(Need for any additional anti Hypertensive medication postpartum)
研究者
Dr Maheshwari GK
Jawaharlal Nehru Medical College , KLE Belagavi