The Predictors of ICU Admission of Obstetric Posterion Reversible Encephalopathy Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 366
- 试验地点
- 1
- 主要终点
- severity of the edema
研究概览
简要总结
The purpose of this study is to explore the predictors of ICU admission of obstetric posterior reversible encephalopathy syndrome.
详细描述
The investigators retrospectively collected data (General information, clinical data, biochemical indicators, imaging features, and pregnancy outcome) from pregnant woman diagnosed with PRES to explore the predictors of ICU admission during 2012 to 2021.Then, the investigators grouped all the patients into ICU group and Non-ICU group according to ICU admission or not.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 16 Years 至 50 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Pregnant Women were diagnosed of PRES.
- •all patients provided written informed consent
排除标准
- •patients combined with other neurological disorders
- •patients combined with mental illness
结局指标
主要结局
severity of the edema
时间窗: Cranial Imaging was examined immediately at the onset of symptoms, such as s headaches, visual changes, seizures, consciousness impairment.
The extent and severity of the edema observed in the lesion area were graded on a scale of 0-5 by evaluating FLAIR images.(0, normal; 1, limited cortical or subcortical white matter oedema; 2, white matter oedema \> cortical oedema, white matter oedema extending into deep white matter; 3, white matter oedema \> cortex oedema, oedema extending to the ventricular surface; 4, the involved regions substantially extend to the ventricular surface and are almost com- pletely confluent; 5, involved regions are fully confluent and con- tinuous, ventricular deformity due to the oedema).
Blood Pressure(BP)
时间窗: The BP of patients was obtained immediately at the onset of symptoms.
blood pressure including systolic blood pressure (SBP), and diastolic blood pressure (DBP).
pregnancy outcomes
时间窗: The pregnancy outcomes will record immediately when the patients deliver.
The rates of stillbirth and premature birth (gestation less than 37 weeks) in PRES patients.
biochemical parameters
时间窗: Biochemical indicators were collected within 1 week of the hospital stay.
The level of lactate dehydrogenase(LDH) will be measured，and LDH﹥380U/L means a worse outcome.
次要结局
未报告次要终点
研究者
Dunjin Chen
Director of obstetrics
Guangzhou Medical University