Circulating Fibroblast Activation Protein (FAP) As A Marker for Fibroblast-Driven Pathology in Rheumatoid Arthritis and Systemic Sclerosis : Implication for Joint, Skin and Lung Fibrosis
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 111
- 试验地点
- 1
- 主要终点
- Serum fibroblast activation protein (FAP) concentration measured by ELISA in patients with rheumatoid arthritis and systemic sclerosis
研究概览
简要总结
This study aims to measure a blood protein called fibroblast activation protein (FAP), which is linked to tissue scarring and inflammation. A small blood sample will be taken from participants (RA , SSc patients and healthy people ), and the FAP level will be measured and compared with routine clinical examinations, imaging studies, and lung function tests.
The purpose of this study is to improve understanding of disease activity and lung involvement in these conditions and to explore whether FAP could be useful as a blood marker for future patients. Participation in this study will not change the participant's usual medical care.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ≥18 years. Confirmed diagnosis of RA (ACR/EULAR) or SSc (ACR/EULAR).
- •Ability and willingness to provide informed consent. Cooperative patient able to answer questions.
排除标准
- •Patients under 18 years' old
- •Active cancer or history of cancer within 5 years.
- •Other major fibrotic systemic disease that could confound circulating FAP levels.
- •Acute infection at time of sampling.
- •Pregnancy or breastfeeding.
- •Other autoimmune diseases
研究组 & 干预措施
control healthy group
Rheumatoid arthritis patients
systemic sclerosis patients
结局指标
主要结局
Serum fibroblast activation protein (FAP) concentration measured by ELISA in patients with rheumatoid arthritis and systemic sclerosis
时间窗: At baseline (Day 1)
次要结局
- disease activity(baseline)
- pulmonary involvement(baseline)
研究者
Toqa Mahfouz Mohamed Ahmed
assistant lecturer at Rheumatology department, Sohag University Hospital
Sohag University