NCT03543930Unknown不适用
Physiologic Effects of CPAP After Vascular Surgery
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- PaO2/FIO2 ratio
研究概览
简要总结
This study aims to investigate, with a case-crossover design, the effects of a short course of preventive CPAP administered in the immediate postoperative period in patients at high-risk of developing postoperative pulmonary complications undergoing major vascular surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Open or endovascular surgery on the abdominal aorta
- •Surgical procedure requiring general anaesthesia and invasive intraoperative mechanical ventilation
- •Intermediate-high risk of postoperative pulmonary complications (ARISCAT score ≥ 26)
排除标准
- •Prolonged post-operative invasive ventilation
- •Invasive or non-invasive ventilation or oxygen therapy in the last month
- •ASA class IV or V
- •Emergency procedures
- •Pneumothorax or active pulmonary infection
- •Any contraindication to CPAP
- •Prolonged bed rest
- •Patient refusal to participate or to receive preventive CPAP
结局指标
主要结局
PaO2/FIO2 ratio
时间窗: Two hours after the administration of CPAP
Increase of the PaO2/FIO2 ratio compared to the baseline value
次要结局
- Esophageal pressure-time product (PTPes)(Two hours after the administration of CPAP)
研究者
Paolo Pelosi
Prof.
University of Genova
研究点 (1)
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