Investigation of pathogenesis of the symptom gingival bleeding in patients with hemophilia A and B

Recruiting

• Conditions: D66; D67; Hereditary factor VIII deficiency; Hereditary factor IX deficiency

• Registration Number: DRKS00032155
• Lead Sponsor: Zentrum der Zahn-, Mund- und Kieferheilkunde (Carolinum) der Johann Wolfgang Goethe-Universität Frankfurt am Main

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-07-03
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 62

Inclusion Criteria

written informed consent
- Test (patients): hemophilia A or B
Control (probands): no heritary bleeding disorders or medication that interfer with hemostasis

Exclusion Criteria

- disease or condition (e.g., heart valve prothesis) that requires antibiotic prophylaxis for measures (assessment of periodontal probing parameters) causing transitory bacteriemia
- additional bleeding disorder
- intake of drugs that interfere with hemostasis (e.g., ASS)

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
bleeding on probing (BOP): approximatly 30 seconds after assessment of probing pocket depths using a Florida probe (6 sites per tooth: mesio-buccal, centro-buccal, disto-buccal, disto-oral, centro-oral, mesio-oral) assessment whether the respective sites bleed or not.

Secondary Outcome Measures

Name	Time	Method
Gingival Bleeding Index (GBI): a periodontal probe (PCPUNC15, HuFriedy) is run along the gingival margin (maxilla buccal, maxilla oral, mandible buccal, mandible oral) and scored at 6 sites per tooth (mesio-buccal, centro-buccal, disto-buccal, disto-oral, centro-oral, mesio-oral) whether the respective sites bleed or not.