Relationship between time course and dose of vitamin E and oxidative stress in haemodialysis patients: a randomised controlled trial

Phase 4

• Conditions: Oxidative stress in hemodialysis patients; Renal and Urogenital - Kidney disease

• Registration Number: ACTRN12609000608268
• Lead Sponsor: Cognis Pty Ltd

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-07-22
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 54

Inclusion Criteria

Incident and prevalent hemodialysis patients undergoing regular three times per week dialysis
Patients must have elevated oxidative stress defined as F2 isoprostane level > 100 pg/ml

Exclusion Criteria

Patients currently taking vitamin E or having taken it in the previous three months will be excluded
Patients taking warfarin, desimipramine, chlorpromazine and chloroquine will be excluded

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
evels of oxidative stress measured by blood F2 isoprostanes[In the time course study we will continue for 20 bloods will be measured at baseline then every two weeks for 20 weeks<br>In the dose determining study the time point will be no longer than 20 weeks with bloods taken at baseline then two weekly for 20 weeks]

Secondary Outcome Measures

Name	Time	Method
nil[nil]