S9624 Ifosfamide in Treating Patients With Meningeal Tumors
- Conditions
- Adult RhabdomyosarcomaAdult Brain Malignant HemangiopericytomaAdult Malignant MeningiomaChondrosarcomaAdult FibrosarcomaAdult Leiomyosarcoma
- Interventions
- Registration Number
- NCT00003292
- Lead Sponsor
- SWOG Cancer Research Network
- Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of ifosfamide in treating patients with meningeal tumors that have recurred or that cannot be removed surgically.
- Detailed Description
OBJECTIVES:
* Estimate failure free survival, overall survival, and response in patients with residual or recurrent/progressive aggressive meningeal tumors (malignant meningioma, hemangiopericytoma, and primary nervous system sarcoma) treated with ifosfamide.
* Evaluate toxicities of ifosfamide in this patient population.
OUTLINE: All patients receive ifosfamide IV continuously over 72 hours on days 1-3 of each 21 day treatment course. Patients are evaluated for response/progression after every 2 courses. Patients with stable disease receive up to 8 courses of therapy. Treatment continues in the absence of disease progression or unacceptable toxicity.
Patients are followed every 3 months for 1 year, then every 6 months thereafter.
PROJECTED ACCRUAL: Approximately 35 patients will be accrued for this study.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 7
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description ifosfamide ifosfamide ifosfamide
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (70)
San Juan City Hospital
🇵🇷San Juan, Puerto Rico
CCOP - Cedar Rapids Oncology Project
🇺🇸Cedar Rapids, Iowa, United States
Mercy Medical Center
🇺🇸Des Moines, Iowa, United States
Iowa Lutheran Hospital
🇺🇸Des Moines, Iowa, United States
NYU School of Medicine's Kaplan Comprehensive Cancer Center
🇺🇸New York, New York, United States
Albert Einstein Clinical Cancer Center
🇺🇸Bronx, New York, United States
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
🇺🇸Baltimore, Maryland, United States
Emory University Hospital - Atlanta
🇺🇸Atlanta, Georgia, United States
CCOP - Central Illinois
🇺🇸Decatur, Illinois, United States
Veterans Affairs Medical Center - New York
🇺🇸New York, New York, United States
Tuft-New England Medical Center
🇺🇸Boston, Massachusetts, United States
CCOP - Illinois Oncology Research Association
🇺🇸Peoria, Illinois, United States
CCOP - Evanston
🇺🇸Evanston, Illinois, United States
Beth Israel Deaconess Medical Center
🇺🇸Boston, Massachusetts, United States
CCOP - Carle Cancer Center
🇺🇸Urbana, Illinois, United States
Veterans Affairs Medical Center - Atlanta (Decatur)
🇺🇸Decatur, Georgia, United States
CCOP - Columbus
🇺🇸Columbus, Ohio, United States
Veterans Affairs Medical Center - Pittsburgh
🇺🇸Pittsburgh, Pennsylvania, United States
CCOP - Iowa Oncology Research Association
🇺🇸Des Moines, Iowa, United States
Iowa Methodist Medical Center
🇺🇸Des Moines, Iowa, United States
MBCCOP - University of New Mexico HSC
🇺🇸Albuquerque, New Mexico, United States
James P. Wilmot Cancer Center
🇺🇸Rochester, New York, United States
University of Pittsburgh Cancer Institute
🇺🇸Pittsburgh, Pennsylvania, United States
Ireland Cancer Center
🇺🇸Cleveland, Ohio, United States
Veterans Affairs Medical Center - San Juan
🇵🇷San Juan, Puerto Rico
CCOP - Oklahoma
🇺🇸Tulsa, Oklahoma, United States
Veterans Affairs Medical Center - Brooklyn
🇺🇸Brooklyn, New York, United States
MBCCOP - San Juan
🇵🇷San Juan, Puerto Rico
Drexel University Hospital
🇺🇸Philadelphia, Pennsylvania, United States
CCOP - Merit Care Hospital
🇺🇸Fargo, North Dakota, United States
Instituto de Enfermedades Neoplasicas
🇵🇪Lima, Peru
Cleveland Clinic Taussig Cancer Center
🇺🇸Cleveland, Ohio, United States
Milton S. Hershey Medical Center
🇺🇸Hershey, Pennsylvania, United States
CCOP - Sioux Community Cancer Consortium
🇺🇸Sioux Falls, South Dakota, United States
Indiana University Cancer Center
🇺🇸Indianapolis, Indiana, United States
Veterans Affairs Medical Center - Indianapolis (Roudebush)
🇺🇸Indianapolis, Indiana, United States
Veterans Affairs Medical Center - Minneapolis
🇺🇸Minneapolis, Minnesota, United States
University of Minnesota Cancer Center
🇺🇸Minneapolis, Minnesota, United States
Veterans Affairs Medical Center - Fargo
🇺🇸Fargo, North Dakota, United States
CCOP - Colorado Cancer Research Program, Incorporated
🇺🇸Denver, Colorado, United States
Mayo Clinic Cancer Center
🇺🇸Rochester, Minnesota, United States
CCOP - Missouri Valley Cancer Consortium
🇺🇸Omaha, Nebraska, United States
Medical College of Wisconsin Cancer Center
🇺🇸Milwaukee, Wisconsin, United States
Veterans Affairs Medical Center - Milwaukee (Zablocki)
🇺🇸Milwaukee, Wisconsin, United States
CCOP - Kalamazoo
🇺🇸Kalamazoo, Michigan, United States
CCOP - Scottsdale Oncology Program
🇺🇸Scottsdale, Arizona, United States
Veterans Affairs Medical Center - Palo Alto
🇺🇸Palo Alto, California, United States
City of Hope Comprehensive Cancer Center
🇺🇸Duarte, California, United States
Stanford University Medical Center
🇺🇸Stanford, California, United States
CCOP - Christiana Care Health Services
🇺🇸Newark, Delaware, United States
Veterans Affairs Medical Center - Gainesville
🇺🇸Gainesville, Florida, United States
CCOP - Geisinger Clinic and Medical Center
🇺🇸Danville, Pennsylvania, United States
Kimmel Cancer Center of Thomas Jefferson University - Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
Fox Chase Cancer Center
🇺🇸Philadelphia, Pennsylvania, United States
CCOP - St. Vincent Hospital Cancer Center, Green Bay
🇺🇸Green Bay, Wisconsin, United States
Veterans Affairs Medical Center - Madison
🇺🇸Madison, Wisconsin, United States
CCOP - MainLine Health
🇺🇸Wynnewood, Pennsylvania, United States
University of Wisconsin Comprehensive Cancer Center
🇺🇸Madison, Wisconsin, United States
CCOP - Marshfield Medical Research and Education Foundation
🇺🇸Marshfield, Wisconsin, United States
Westmead Hospital
🇦🇺Westmead, New South Wales, Australia
Cancer Institute of New Jersey
🇺🇸New Brunswick, New Jersey, United States
Veterans Affairs Medical Center - Tampa (Haley)
🇺🇸Tampa, Florida, United States
H. Lee Moffitt Cancer Center and Research Institute
🇺🇸Tampa, Florida, United States
MBCCOP - LSU Health Sciences Center
🇺🇸New Orleans, Louisiana, United States
CCOP - Ochsner
🇺🇸New Orleans, Louisiana, United States
CCOP - Michigan Cancer Research Consortium
🇺🇸Ann Arbor, Michigan, United States
CCOP - Southern Nevada Cancer Research Foundation
🇺🇸Las Vegas, Nevada, United States
CCOP - Northern New Jersey
🇺🇸Hackensack, New Jersey, United States
Alegent Health-Midlands Community Hospital
🇺🇸Papillion, Nebraska, United States
Veterans Affairs Medical Center - East Orange
🇺🇸East Orange, New Jersey, United States