Using High-resolution Electroencephalography to Optimize the Evaluation of Awareness in Patients With Disorders of Consciousness
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 28
- Primary Endpoint
- Number of participants showing differences of electrophysiological activity after personalized but not standard stimulation protocols
Study Overview
Brief Summary
The purpose of this study is to evaluate whether personalized stimulations can improve the detection of electrophysiological signs of awareness in patients with disorders of consciousness.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •patients in a vegetative state or a minimally conscious state
- •agreement from families
Exclusion Criteria
- •patients with akinetic mutism or locked-in syndrome
- •patients in a coma
- •patients with damages in the inner or middle ear
- •contraindication to a high-density electroencephalography exam
Arms & Interventions
electroencephalography recording
Cerebral measurements from high-density electroencephalography after the presentation of personalized stimulations
Intervention: high-density electroencephalography (Device)
Outcomes
Primary Outcomes
Number of participants showing differences of electrophysiological activity after personalized but not standard stimulation protocols
Time Frame: standard stimulations: 28 days after recruiting patients
Depending of the personalized stimulation protocol, the differences of electrophysiological activity can the presence of event-related potentials (N100, mismatch negativity, P300, etc.) or alterations of neural oscillations. The personalized stimulation protocol will be chosen according to the families' feeling of a presence.
Secondary Outcomes
No secondary outcomes reported