Optimizing the Evaluation of Awareness in Disorders of Consciousness
Not Applicable
- Conditions
- Disorders of Consciousness
- Interventions
- Device: high-density electroencephalography
- Registration Number
- NCT02628639
- Lead Sponsor
- Centre Hospitalier Universitaire de Besancon
- Brief Summary
The purpose of this study is to evaluate whether personalized stimulations can improve the detection of electrophysiological signs of awareness in patients with disorders of consciousness.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 28
Inclusion Criteria
- patients in a vegetative state or a minimally conscious state
- agreement from families
Exclusion Criteria
- patients with akinetic mutism or locked-in syndrome
- patients in a coma
- patients with damages in the inner or middle ear
- contraindication to a high-density electroencephalography exam
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description electroencephalography recording high-density electroencephalography Cerebral measurements from high-density electroencephalography after the presentation of personalized stimulations
- Primary Outcome Measures
Name Time Method Number of participants showing differences of electrophysiological activity after personalized but not standard stimulation protocols standard stimulations: 28 days after recruiting patients Depending of the personalized stimulation protocol, the differences of electrophysiological activity can the presence of event-related potentials (N100, mismatch negativity, P300, etc.) or alterations of neural oscillations.
The personalized stimulation protocol will be chosen according to the families' feeling of a presence.
- Secondary Outcome Measures
Name Time Method