NCT00047762已完成1 期
Open-Label, Multicenter, Dose-Escalation Study in Subjects w/Advanced Colorectal Cancer to Evaluate the Safety, Efficacy, and Pharmacokinetics of Tarceva in Combination w/5-Fluorouracil, Leucovorin, and Irinotecan and of Bevacizumab in Combination w/Tarceva, 5-Fluorouracil, Leucovorin, and Irinotecan
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 试验地点
- 3
研究概览
简要总结
The purpose of this study is test the safety of Tarceva, find the best dose, and see what effects (good and bad) it has on you and your colorectal cancer. The effects of Tarceva will be evaluated in combination with 5-fluorouracil, leucovorin, and irinotecan, with or without Bevacizumab.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects must fulfill all of the following criteria to be eligible for study entry:
- •Signed informed consent
- •At least 18 years of age
- •Histologically confirmed metastatic colorectal adenocarcinoma of the colon or rectum
- •Resected or biopsied primary tumors or metastatic site will serve as the basis for histologic confirmation.
- •Measurable disease (defined as at least one dimension >2 cm [>1 cm on spiral CT scans])
- •ECOG performance status of 0 or 1
- •Life expectancy >3 months
- •Use of an effective means of contraception in men and in women of childbearing potential
- •Ability to comply with study and follow-up procedures
排除标准
- 未提供
研究者
研究点 (3)
Loading locations...
相似试验
招募中
1 期
A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)Advanced Solid TumorMetastatic Solid TumorSoft Tissue Sarcoma (STS)Platinum-resistant Ovarian Cancer (PROC)Hepatocellular Carcinoma (HCC)Colorectal Cancer (CRC)HER2 Negative Breast CancerRenal Cell Carcinoma (RCC)Cutaneous MelanomaNCT05824975GI Innovation, Inc.358
已完成
1 期
A Dose-escalation Study to Assess the Safety, Tolerability, and Pharmacokinetics of GDC-0032 in Combination With Docetaxel or With Paclitaxel in Patients With HER2-negative Locally Recurrent or Metastatic Breast Cancer or Non-small Cell Lung CancerBreast Cancer, Non-small Lung CancerNCT01862081Genentech, Inc.80
进行中（未招募）
1 期
A First-in-Human Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7507062 in Participants With Systemic Lupus ErythematosusSystemic Lupus ErythematosusNCT05835986Hoffmann-La Roche70
已完成
1 期
A Study of KW-2478 in Combination With Bortezomib in Subjects With Relapsed and/or Refractory Multiple MyelomaMultiple MyelomaNCT01063907Kyowa Kirin Co., Ltd.95
已完成
1 期
Study of TAK-733 in Adult Patients With Advanced Nonhematologic MalignanciesAdvanced Non-hematologic MalignanciesAdvanced Metastatic MelanomaNCT00948467Millennium Pharmaceuticals, Inc.51