Drug Use Evaluation of Clindamycin in Critical Care Units in Alexandria Main University Hospital

Completed

• Conditions: Infection, Bacterial

• Registration Number: NCT05223400
• Lead Sponsor: Alexandria University

Brief Summary

Irrational use of antibiotics is a one of the main health system problems,it leads to antibiotic resistance,increasing antibiotics side effects and the total cost. This study is a medication use evaluation study aims to evaluate intravenous clindamycin prescribing practice in critical care units in Alexandria Main University Hospital.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-01-06
• Study First Submitted QC: 2022-02-02
• Study First Posted: 2022-02-04
• Study Start: 2022-03-01
• Primary Completion: 2022-04-01
• Study Completion: 2022-04-01
• Status Verified: 2023-02
• Last Update Submitted: 2023-02-02
• Last Update Posted: 2023-02-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 99

Inclusion Criteria

• Adults 18 years old or more .
• Patients on clindamycin as an empirical treatment.
• Patients started clindamycin as an emperical treatment in other departments but the physician approved to continue it in critical care.

Exclusion Criteria

• Children (less than 18 years old)
• Patients started clindamycin as a defenitive treatment (based on microbiological culture results).

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
the number of prescriptions with appropriate indications of clindamycin will be counted during the retrospective observation of all prescriptions	1 month	appropriateness of clindamycin indication will be determined according to IDSA guidelines.

Secondary Outcome Measures

Name	Time	Method
the number of prescriptions with duplication of therapy with clindamycin will be counted during the retrospective observation of all prescriptions	1 month	duplication of therapy means prescribing of clindamycin concurrently with another antibiotic to target the same microorganism.
the number of patients who had diarrhea as a main side effect of clindamycin	1 month	diarrhea is a main side effect of clindamycin so in the study the number of patients who had diarrhea will be counted during the retrospective observation of all prescriptions
the number of patients who had severe drug interactions with clindamycin	1 month	in the study the number of patients who severe clindamycin drugs interactions will be counted during the retrospective observation of all prescriptions
to calculate the total cost of clindamycin.	1 month	The cost of clindamycin treatment courses of all patients will be calculated in the Egyptian pound
Total clindamycin DDD defined daily doses and clindamycin defined daily doses per 1000 patients days.	1 month	Defined daily doses measurement of a drug is an indicator put by WHO , it indicates the consumption of this drug in a hospital or a department and defined daily doses per 1000 patients days indicates the consumption of this drug in relation to the total number of patients in a certain period of time.

Trial Locations

Locations (1)

Faculty of Mdicine; 🇪🇬 Alexandria, Egypt