NCT00152048已完成4 期
A 24 Week Randomised Double Blind Placebo Controlled Study to Evaluate the Atrophogenic Potential of Eflornithine in the Treatment of Women With Excessive Facial Hair
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- Allergan
- 入组人数
- 78
- 主要终点
- Change in facial skin thickness measured by ultrasound at 24 weeks
研究概览
简要总结
The purpose of this study is to evaluate whether regular use of eflornithine 11.5% cream in treating women with facial hair will induce skin damage (atrophy) on the face and/or forearms
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Female subjects with clinical diagnosis of facial hirsutism/excessive facial hair
- •Women of childbearing potential must agree to use an effective form of birth control for the duration of the study
- •Skin type I-IV
- •Customary frequency of removal of facial hair two or more times per week
排除标准
- •Pregnant or lactating women
- •Severe inflammatory acne or presence of significant scarring on the face
- •History of skin malignancy
- •Connective tissue disorders
结局指标
主要结局
Change in facial skin thickness measured by ultrasound at 24 weeks
次要结局
- Skin biopsies
- Histology and histochemistry in the dermis
- Physician Global Assessment
- Subject Self-Assessment Questionnaire
研究者
相似试验
进行中（未招募）
3 期
S0820, Adenoma and Second Primary Prevention TrialColorectal NeoplasmsNCT01349881SWOG Cancer Research Network354
已完成
不适用
A double-blind placebo-controlled study on the effect of cerivastatin on the process of atherosclerosis in non-insulin-dependent diabetes mellitusDiabetes mellitus type II (DM type II)Nutritional, Metabolic, EndocrineDiabetesISRCTN51822988eiden University Medical Centre (LUMC) (Netherlands)250
已完成
2 期
Effect of 15% Eflornithine Hydrochloride Cream on African-American Males With Pseudofolliculitis BarbaePseudofolliculitis BarbaeNCT00176995Hordinsky, Maria K., MD15
终止
2 期
Evaluation of the Efficacy of Fomepizole in the Treatment of Acetaminophen OverdoseAcetaminophenDrug OverdoseAcetaminophen OverdoseDrug-induced Liver InjuryLiver ToxicityLiver FailureAcetaminophen PoisoningNCT05517668Richard Dart, MD, PhD29
已完成
3 期
A Study Comparing the Safety and Efficacy of 0.5% Ivermectin Cream to Placebo in Lice Infested SubjectsHead LiceNCT01068158Topaz Pharmaceuticals Inc371