International Cancer of the Head and Neck, Genetics and Environment (InterCHANGE) Study

• Conditions: Assess the Effect of Genetic Factors, Including Both SNP and Copy Number Variation (CNV) Through Analysis of Both Main Effect and Gene-gene Interaction; Evaluate the Association Between Certain Environmental Exposures (e.g. Cigarette Smoking, Alcohol Drinking, Betel Nut Chewing…) and Head and Neck Cancers

• Registration Number: NCT01972802
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

Our overall objective is to understand the role of lifestyle factors, genetics and HPV infection in the development and prognosis of head and neck cancer particularly in Asia.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-01
• Status Verified: 2013-10
• Study First Submitted: 2013-10-24
• Study First Submitted QC: 2013-10-29
• Last Update Submitted: 2013-10-29
• Study First Posted: 2013-10-30
• Last Update Posted: 2013-10-30
• Primary Completion: 2014-12
• Study Completion: 2014-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 900

Inclusion Criteria

Age 18~80 Incident head and neck cancer patients

• Oral, oropharynx and hypopharynx (C00-C14)
• Laryngreal cancer (C32)
• *Esophageal cancer if possible (C15)

Exclusion Criteria

• Salivary gland (C07-C08)
• Nasopharynx (C11)
• Thyroid (C79.3)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
head and neck cancer risk factor	Four years	evaluate the association between certain environmental exposures (e.g. cigarette smoking, alcohol drinking, betel nut chewing...) and head and neck cancers,assess the effect of genetic factors, including both SNP and copy number variation (CNV) through analysis of both main effect and gene-gene interaction

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Tiapei, Taipei, Taiwan