Immune Response Features in Allergic Airway Diseases

• Conditions: Allergic Asthma; Allergic Rhinitis
• Interventions: Procedure: Nasal provocation test

• Registration Number: NCT04352088
• Lead Sponsor: Lithuanian University of Health Sciences

Brief Summary

This study aims to investigate immune mechanisms and phenotypes and endotypes of allergic airway diseases - allergic rhinitis and allergic asthma. Pathogenesis of these diseases are not fully investigated yet. Patients with the same disease have different dominant symptoms, course of the disease and response to treatment. Moreover, there is a hypothesis about united airway disease suggesting that allergic rhinitis and allergic asthma is different manifestation of the same disease. This led to assumption of phenotypes and endotypes. This classification which still is not unified can let to prescribe personalized treatment for every patient.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-05-01
• Status Verified: 2020-04
• Study First Submitted: 2020-04-15
• Study First Submitted QC: 2020-04-16
• Last Update Submitted: 2020-04-16
• Study First Posted: 2020-04-17
• Last Update Posted: 2020-04-17
• Primary Completion: 2022-11
• Study Completion: 2024-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• Hypersensitivity to house dust mites
• Allergic rhinitis with or without mild to moderate asthma

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Exclusion Criteria

• Acute or chronic infections
• Use of systemic immunosupresants (wait 1 month)
• Use of systemic or local antihistamines (wait 1 week)
• Use of intranasal steroids (wait 1 month)
• Oncological or active autoimmune diseases

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Allergic rhinitis patients	Nasal provocation test	-
Allergic rhinitis and asthma patients	Nasal provocation test	-
Healthy individuals	Nasal provocation test	-

Primary Outcome Measures

Name	Time	Method
Cytokines level in nasal lavage and peripheral blood after nasal provocation test in different groups.	22 hours	Cytokines (IL-13, IL-10, IL-22, etc.) level will be measured by ELISA before and after nasal provocation test with house dust mites.

Trial Locations

Locations (1)

Hospital of Lithuanian University of Health Sciences Kauno klinikos; 🇱🇹 Kaunas, Lithuania