Investigation of Phenotypes, Endotypes and Immune Response Features in Allergic Airway Diseases
试验速览
- 阶段
- 不适用
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Cytokines level in nasal lavage and peripheral blood after nasal provocation test in different groups.
研究概览
简要总结
This study aims to investigate immune mechanisms and phenotypes and endotypes of allergic airway diseases - allergic rhinitis and allergic asthma. Pathogenesis of these diseases are not fully investigated yet. Patients with the same disease have different dominant symptoms, course of the disease and response to treatment. Moreover, there is a hypothesis about united airway disease suggesting that allergic rhinitis and allergic asthma is different manifestation of the same disease. This led to assumption of phenotypes and endotypes. This classification which still is not unified can let to prescribe personalized treatment for every patient.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Hypersensitivity to house dust mites
- •Allergic rhinitis with or without mild to moderate asthma
排除标准
- •Acute or chronic infections
- •Use of systemic immunosupresants (wait 1 month)
- •Use of systemic or local antihistamines (wait 1 week)
- •Use of intranasal steroids (wait 1 month)
- •Oncological or active autoimmune diseases
结局指标
主要结局
Cytokines level in nasal lavage and peripheral blood after nasal provocation test in different groups.
时间窗: 22 hours
Cytokines (IL-13, IL-10, IL-22, etc.) level will be measured by ELISA before and after nasal provocation test with house dust mites.
次要结局
未报告次要终点
研究者
Brigita Sitkauskiene
Prof., Head of Department of Immunology and Allergology
Lithuanian University of Health Sciences