A prospective, randomised, double-blind, placebo-controlled trial to assess the respiratory effects of oxycodone versus morphine in anaesthetised patients
- Conditions
- Surgery: AnaesthesiaSurgeryAnaesthesia
- Registration Number
- ISRCTN30198912
- Lead Sponsor
- Record Provided by the NHSTCT Register - 2007 Update - Department of Health
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
1. Patients aged 18-55 years
2. Patients who are ASA 1-2
3. Patients must be inpatients
4. Patients who are due to undergo surgery of greater than 30 minutes duration under GA
5. Patient has given written informed consent
6. Patient weighs between 45 and 100kg, and/or BMI =30
1. Patients who are allergic to oxycodone, naloxone or morphine
2. Patients with a history of substance abuse
3. Patients with a history of anaesthetic complications
4. Patients who have been on long-term opioid therapy, or have taken strong opioids within the last two weeks
5. Patients who are considered unsuitable by the responsible anaesthetist - for whom the required lengthening of the anaesthesia time is deemed to constitute an unacceptable increased risk
6. Patients who are involved in existing research
7. Patients who have any condition predisposing to respiratory depression
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method