PROCalcitonin-based algorithm for antibiotic use in Acute Pancreatitis: a randomised controlled trial

Manchester University NHS Foundation Trust0 个研究点目标入组 260 人开始时间: 2018年2月7日最近更新: 2022年8月15日

适应症

试验速览

2019 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/31358032 protocol (added 31/07/2019) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35863358/ (added 22/07/2022)

•Adult patients presenting with acute pancreatitis admitted or referred to the service. Inclusion criteria include:
•1. Patients over the age of 18 years of age
•2. Ability to provide informed consent
•3. The diagnosis of acute pancreatitis requires two of the following three features:
•3.1. Abdominal pain consistent with acute pancreatitis (acute onset of a persistent, severe, epigastric pain often radiating to the back)
•3.2. Serum lipase activity (or amylase activity) at least three times greater than the upper limit of normal
•3.3. Characteristic findings of acute pancreatitis on contrast-enhanced computed tomography (CECT) and less commonly magnetic resonance imaging (MRI) or transabdominal ultrasonography

•1. Patients under the age of 18 years of age
•2. Patients who are unable to give informed consent (criterion removed 14/06/2019)
•3. Infectious conditions requiring prolonged antibiotic therapy – such as infective endocarditis
•4. Severely immunocompromised patients – such as those with human immunodeficiency virus and with a CD4 count of less than 200 cells/mm3; neutropenic patients (<500 neutrophils/mm3)
•5. Patients on immunosuppressive therapy
•6. Previous thyroid surgery

发起方