Resting Postural Tremor in Multiple Sclerosis

Recruiting

• Conditions: Multiple Sclerosis

• Registration Number: NCT04405479
• Lead Sponsor: Charles University, Czech Republic

Brief Summary

Early diagnosis is a key factor for effective treatment of multiple sclerosis. Accelerometer and gyroscope measurement of tremor could screen potential motor control dysfunction and predict a risk for development of multiple sclerosis.

Detailed Description

The aim of this study is to test whether specially developed accelerometer and gyroscope can differentiate pattern of resting postural tremor in healthy and people with multiple sclerosis.

Spectral analysis and the correlation of the average signal spectra will be computed. Moreover, categorization based on the tremor component according to the maximum likelihood estimation will be done.

Study Timeline

• Study First Submitted: 2020-05-20
• Study First Submitted QC: 2020-05-27
• Study First Posted: 2020-05-28
• Study Start: 2021-05-01
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-05
• Last Update Posted: 2024-02-06
• Primary Completion: 2024-10-28
• Study Completion: 2024-12-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Group 1:

• Definite diagnosis of MS
• prevailed motor deficit of upper extremities, but without visible tremor
• stable clinical status in the preceding 3 months
• Expanded Disability Status Scale score (EDSS) ≥ 2 ≤ 7.5, and
• no corticosteroid therapy in the preceding month

Group 2:

• Healthy volunteers in the age of 20-70 years will be employed
• There will be defined as persons without any neurological disease diagnose at the time of the measurement.

Exclusion Criteria (both groups):

Patients with factors disturbing mobility (e.g. stroke, pregnancy, fractures) were excluded from the study.

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Tremor	baseline	accelerometer (1 m·s-2)

Secondary Outcome Measures

Name	Time	Method
Psychomotor processing speed	baseline	Coin Rotation Task
Hand grip strength	baseline	Hand dynamometer JAMA
Hand and arm function	baseline	Nine Hole Peg Test

Trial Locations

Locations (3)

Department of neurology; 🇨🇿 Prague, Czechia

Deparment of revmatology and rehabilitation; 🇨🇿 Prague, Czechia

Kamila Řasová; 🇨🇿 Praha, Czechia