Comparison Between Transcranial Stimulation Protocols With Continuous Current in the Chronic Migraine
- Conditions
- Chronic Migraine
- Interventions
- Other: tDCS
- Registration Number
- NCT03414203
- Lead Sponsor
- Federal University of Paraíba
- Brief Summary
This study aims to compare the effects of transcranial direct current stimulation on the clinical and cognitive function in patients with chronic migraine.
- Detailed Description
The patients will be randomized into 1 of 3 groups: active tDCS for 15 minutes, active tDCS for 15 minutes, with an interval of 20 minutes and more 15 minutes os stimulation, sham tDCS for 15 minutes. The tDCS will be applied for 10 days over 2 weeks.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 31
- females
- clinical diagnosis of chronic migraine according to the International Classification of Headaches Disorders (ICHD-3 beta).
- headache attributable to some pathological condition, associated neurologic or neuropsychiatric disease
- use of central nervous system modulating drugs
- pregnancy
- metallic head implants
- use of a cardiac pacemaker
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description sham tDCS tDCS Sham tDCS for 15 minutes for 10 days over 2 weeks. The stimulation is non-active. Placement: anode - left DLPFC; cathode - right supraorbital region active tDCS tDCS Active tDCS for 15 minutes for 10 days over 2 weeks. Intensity: 2 milliampere. Placement: anode - left DLPFC; cathode - right supraorbital region active tDCS with interval tDCS Active tDCS for 15 minutes, interval of 20 minutes and more 15 minutes for 10 days over 2 weeks. Intensity: 2 milliampere. Placement: anode - left DLPFC; cathode - right supraorbital region
- Primary Outcome Measures
Name Time Method Migraine Disability Assessment - MIDAS "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" Change in perform activities of daily living associate to migraine assessed on the Migraine Disability Assessment - MIDAS.
- Secondary Outcome Measures
Name Time Method Wechsler Intelligence Scale Numbers Test "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" Change in cognitive ability assessed on the Wechsler Adult Intelligence Scale Numbers Test
Visual Attention Test (Attention Matrices) "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" Change in selective attention assessed on the Visual Attention Test (Attention Matrices)
Headache Impact Test - HIT-6 "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" Change in quality of life associate to migraine assessed on the Headache Impact Test-6 (HIT-6)
Nine Hole Peg Test "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" Change in the motor processing speed assessed on the Nine Hole Peg Test
Concentrated Attention Test "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" Change in selective attention assessed on the Concentrated Attention Test
Montreal Cognitive Assessment "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" Change in cognition assessed on the Montreal Cognitive Assessment
Side Effects Questionnaire "every day for up to 2 weeks" adverse effects assessment
Trail Making Test part B "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" Change in executive functions assessed on the Trail Making Test part B
Hayling's Test Hayling's Test "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" Change in operational memory assessed on the Hayling's Test Evaluate operational memory
Salthouse Visual Patterns and Lyrics "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" Change in visual processing speed assessed on the Salthouse Visual Patterns and Lyrics
Wechsler Intelligence Scale Letters "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" Change in cognitive ability assessed on the Wechsler Adult Intelligence Scale Letters
Paced Auditory Serial Addition Task "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" Change in selective attention assessed on the Paced Auditory Serial Addition Task
Trial Locations
- Locations (1)
Federal University of Paraiba
🇧🇷João Pessoa, Paraiba, Brazil