The Effect of Overground Walking on the Increase of Brain-Derived Neurotrophic Factor Levels, IL-6, HS-CRP, Cognitive Function, and Quality of Life in the Elderly
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- ADQOL
研究概览
简要总结
The purpose of this research is to investigate the impact of overground walking as a part of a rehabilitation program on the increase in Brain-derived neurotrophic factor (BDNF) levels, decrease in IL-6 levels, decrease in hs-CRP levels, improvement in cognitive function, and enhancement of quality of life (QOL) in older people with mild cognitive impairment. These findings are anticipated to contribute to the efforts to elevate BDNF levels, cognitive function, and QOL while reducing IL-6 and hsCRP levels in the elderly with mild cognitive impairment.
详细描述
This research employs a quasi-experimental research design using a Pretest-Posttest Design approach. The Pretest-Posttest method is executed by assessing before and after the intervention within the same group.
All research subjects receive the same treatment, which involves participating in an overground walking program on a flat surface. The selected research subjects are provided with an explanation of the research's objectives and benefits and the exercise and examination procedures, then sign the informed consent.
Research subjects are instructed to walk on a flat surface for a distance of 15 meters, with a duration of 20 minutes, increasing by 5 minutes each week until the target heart rate is achieved during the exercise. After an 8-week post-intervention period, research subjects will undergo a follow-up examination.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Mild cognitive impairment (MoCA INA Score 19-25 out of 30
- •Barthel Index Score 20
- •Geriatric Depression Scale Score ≤ 5
- •Timed Up and Go Test < 15 seconds)
- •Capable of comprehending verbal and written instructions
- •Capable of walking unassisted
排除标准
- •The presence of hearing impairment that could hinder the subject from receiving verbal instructions,
- •The presence of uncorrected visual impairment
- •Having musculoskeletal disorders
- •Receiving other rehabilitation programs,
- •Presence of diseases causing cognitive impairment
- •Severe joint diseases such as osteoarthritis and rheumatoid arthritis that may worsen during exercise or could pose difficulties in carrying out the exercise program,
- •Severe cardiovascular diseases as diagnosed by a Cardiologist
研究组 & 干预措施
Subjects
干预措施: Overground Walking (Other)
结局指标
主要结局
ADQOL
时间窗: 8 weeks
Alzheimer disease Quality of Life
BDNF
时间窗: 8 weeks
Brain-derived neurotrophic factor level
IL6
时间窗: 8 weeks
Interleukin-6 level
hsCRP
时间窗: 8 weeks
hs-CRP level
MoCAINA
时间窗: 8 weeks
MONTREAL COGNITIVE ASSESSMENT INDONESIA
次要结局
未报告次要终点
研究者
Irma Ruslina Defi
Principal Investigator
Universitas Padjadjaran