Sleep quality in adolescents with depressive symptoms: neurohormonal and psychophysiological accompanying factors

• Conditions: F32.0; F33.1; Severe depressive episode without psychotic symptoms; Recurrent depressive disorder, current episode mild; Adjustment disorders; F32.1; F33.2; F43.2; F32.2; Recurrent depressive disorder, current episode severe without psychotic symptoms

• Registration Number: DRKS00020907
• Lead Sponsor: Klinik und Poliklinik für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie der Universität Regensburg am Bezirksklinikum Regensburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-04-08
• Study Completion: 2022-10-28
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 66

Inclusion Criteria

General inclusion criteria of the index and control group
•Age at the time of examination:
12 -18 years
•Informed consent and signed declaration of consent of study participants and their parents/ legal representatives
•Sufficient understanding of the German language
•No intake of psychotropic drugs or glucocorticoid-containing drugs

Inclusion criteria of the index group
•Depressive disorder according the diagnostic criterias of ICD-10 (including F32.0-Mild depressive episode, F32.1-Moderate depressive episode, F32.2-
Severe depressive episode without psychotic symptoms, F 43.21- Adjustment disorder with longer depressed mood, F33.0 Recurrent depressive disorder, current episode mild, F33.1 Recurrent depressive disorder, current episode moderate, F33.2 Recurrent depressive disorder, current episode severe without psychotic symptoms)

Inclusion criteria of the control group
•No history of psychiatric or neurological diseases
•No current psychiatric illness requiring treatment

Exclusion Criteria

General exclusion criteria of the index and control group
•Lacking informed consent or signed declaration of consent of study participants or their parents/ legal representatives
•Acute psychiatric condition or psychotic disorder, which may affect the ability to consent
•Acute suicidality
•Pregnancy
•Intake of antidepressant drugs or glucocorticoid-containing drugs
•Cannabis use within 3 months before participation
•Neurological or endocrinological diseases, which may affect brain physiology or relevant endocrinological parameters (especially diseases concerning hypothalamus, hypophysis and the adrenal glands)

Exclusion criteria of the index group
•comorbid anxiety disorder, emotional disorder as well as social behaviour disorder are no exclusion criteria, furthermore no psychiatric comorbidities (exclusion comorbidities: schizophrenia, post-traumatic stress disorder, attention deficit hyperactivity disorder, bipolar disorder, autism spectrum disorder, obsessive-compulsive disorder, dissociative disorders, sleep-wakefulness disturbances, eating disorder, substance use disorder)

Exclusion criteria of the control group
•Meeting criteria of ICD-10 or DSM-5 depressive disorder
•Current or past psychiatric or neurological disorder
•Current or past psychiatric or psychotherapeutic treatment

Study & Design

• Study Type: observational
• Study Design: Not specified