Platelet Rich Fibrin Against Connective Tissue Graft in Treatment of Gingival Recessions
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Gingival recession depth
研究概览
简要总结
The main objective of this study was to evaluate the clinical effectiveness of platelet-rich fibrin membrane used in combination with a coronally advanced flap and to compare it with the use of a subepitelial connective tissue graft in combination with a coronally advanced flap in Miller class I-II bilateral gingival recession treatment
详细描述
Purpose
The main objective of this study was to evaluate the clinical effectiveness of platelet-rich fibrin (PRF) in combination with modified coronally advanced flap (MCAF) in the treatment of multiple gingival recessions. Furthermore the second aim of the present study was to compare plastic periodontal surgical procedure, with PRF membrane and connective tissue graft, by a randomized splitmouth controlled study.
Clinical effectiveness of platelet-rich fibrin (PRF) in combination with modified coronally advanced flap (MCAF) as measured by Clinical measurements.
Material and Methods
Twenty patients with multiple gingival recession defects (Miller I, II) participated in this split-mouth trial. Sixty defects received either MCAF+PRF (test) or MCAF with subepithelial connective tissue graft (SCTG) (control). Gingival recession depth (RD), gingival recession width (RW), keratinized tissue width (KTW), recession area (RA), probing depth (PD), clinical attachment level (CAL) and gingival thickness (GT) were evaluated at baseline and 6 months. Additionally post-surgery patient satisfaction and pain status were measured by comparing visual analogue scale (VAS) scores.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •non smoking,
- •similar bilateral Miller Class I or II20 localized gingival recessions at least ≥3 mm, located on incisors, canines or premolars on both jaws,
- •identifiable cemento-enamel junction (CEJ),
- •age ≥18 years,
- •presence of tooth vitality and absence of restorations and superficial caries in the area to be treated,
- •no periodontal surgical treatment on the involved sites,
- •sufficient palatal donor tissue at least ≥2.5 mm thickness for the indicated SCTG
排除标准
- •Patients in a pregnancy or lactation period or with self-reported history of antibiotic medication within 6 months
- •Molar, mobile or fully restorated teeth
结局指标
主要结局
Gingival recession depth
时间窗: 6 months
Change from baseline in gingival recession will be assessed at 6 months
Complete root coverage
时间窗: 6 months
Change from baseline in gingival recession will be assessed at 1, 3 and 6 months.
次要结局
- Keratinized tissue width(6 months)
- Pain scores(first week after operations)
研究者
ELİF ONCU
Assist.Prof.Dr.
Necmettin Erbakan University