The effect of granisetron in prophylaxis of intrathecal opioid induced-pruritus

Not Applicable

• Conditions: intrathecal opioid induced-pruritus.; other pruritus

• Registration Number: IRCT2013072414149N1
• Lead Sponsor: Tehran University of Medical Science

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 180

Inclusion Criteria

inclusion criteria : ASA class I-II
exclusion criteria :male less than 18 years old; male more than 65 years old; fmale less than 18 years old; fmale more than 65 years old; ASA Class III; ASA Class IV; patient refuse from performing spinal block; patients with spinal deformities; patients with mental disorders; patients with local skin infections; history of anaphylaxis to local anesthetics,sufentanil and granisetron; patients with coagulation disorders; patients with severe hepatic disease; patients with renal function disorder; patients with body wheight more than 100 kilograms; patients dependent to opioid; patients with severe chronic obstructive pulmonary disease (FEV1 less than 600cc); height less than 150 cm or more than 180 cm; known cardiac disease; patients with long QTsyndrome

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pruritus. Timepoint: 30 minutes-0.5 to 2 hours - 2 to 4 hours - 4 to 8 hours - 8 to 24 hours after intervention. Method of measurement: Visual Analogue Scales and Verbal Rating Scales for assessment of the severity of pruritus.