Blood Loss Measurement Using Electrical Impedance Tomography

Not Applicable

• Conditions: Blood Loss
• Interventions: Device: Electrical impedance tomography measurement

• Registration Number: NCT05287334
• Lead Sponsor: Czech Technical University in Prague

Brief Summary

The project focuses on the possibility of detecting blood loss using electrical impedance tomography. Based on previous animal experiments, it was found that the bolus of saline significantly affects the signal of chest bioimpedance. It is assumed that blood loss of a similar volume will cause a similar signal change with the opposite trend. The aim of this project is to determine whether there is a significant change in the thoracic electrical impedance tomography signal when blood loss is caused by voluntary blood donation.

Detailed Description

Electrical impedance tomography is a bedside method of ventilation monitoring. The bioimpedance of the tissue depends, among other things, on its blood content. The area of the chest and especially the lungs is a heavily perfused tissue, which also serves as one of the reservoirs of blood in case of blood loss. It is therefore possible that blood loss will be visible on chest bioimpedance relatively soon.

The study will be performed on voluntary blood donors. Blood loss of 450 mL will be caused by the collection of donated blood. During blood collection at the transfusion department, thoracic bioimpedance will be measured using electrical impedance tomography. The resulting signal change will then be analyzed to determine the possibility of detecting and measuring blood loss using electrical impedance tomography.

Study Timeline

• Study First Submitted: 2022-03-10
• Study First Submitted QC: 2022-03-17
• Study First Posted: 2022-03-18
• Study Start: 2022-07-01
• Status Verified: 2022-08
• Last Update Submitted: 2022-08-08
• Last Update Posted: 2022-08-09
• Primary Completion: 2022-10-10
• Study Completion: 2022-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• voluntary blood donation

Exclusion Criteria

• standard exclusion criteria for voluntary blood donation based on the transfusion station protocol
• standard exclusion criteria for electrical impedance tomography according to the manufacturer

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Voluntary blood donors	Electrical impedance tomography measurement	Voluntary blood donors undergoing standard blood donation while measuring electrical impedance of the chest .

Primary Outcome Measures

Name	Time	Method
Change in chest electrical impedance due to blood loss.	Time frame of one voluntary blood donation process (15 min)	A change in the electrical impedance of the chest of a voluntary blood donor caused by a blood donation.

Trial Locations

Locations (2)

Czech technical university in Prague, Facutly of biomedical engineering; 🇨🇿 Kladno, Czechia

Czech Technical University, Faculty of Biomedical Engineering; 🇨🇿 Kladno, Czechia