NCT02353052Unknown不适用
Prospective Cohort Study of the Clinical Applications for the Pathologic Type, Staging, and Grading of Primary Gastrointestinal Stromal Tumor
Shanghai Zhongshan Hospital1 个研究点 分布在 1 个国家目标入组 900 人开始时间: 2013年7月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 900
- 试验地点
- 1
- 主要终点
- Number of participants with tumor recurrence
研究概览
简要总结
Evaluate the reliability of morphology standards for GIST pathologic type, staging and grading by retrospective analyzing clinical data; on this basis, establish a GIST standardized and individualized treatment mode to maximum benefit GIST patients, avoid under- and over-treatment.
详细描述
- Retrospective analysis of GIST cases in the recent five years: the GIST clinical data of Fudan University Zhongshan Hospital from 2007 January to 2012 December were collected. By reviewing the HE slides, GIST was evaluated by 12 indicators, NIH scheme and WHO standard. Accomplish the gene sequencing of KIT, PDGFRA, B-raf, and SDH. Follow up the patients about their treatment and prognosis. Analyze and compare the advantages and disadvantages of the histomorphology indicators, NIH scheme, and WHO standard.
- Organize the first prospective cohort study of GIST individualized treatment based on the histomorphology. Obtain the evidence of histological assessment for GIST by following up patients for 3 years.
- Establish an evaluation criteria based on the morphology of GIST. Make objective evaluations about GIST tumor size, tumor location and gene mutation status in the prognosis estimate. Make rules to effectively guide individualized treatment of GIST.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Number of participants with tumor recurrence
时间窗: 3 years
Number of participants with tumor metastasis
时间窗: 3 years
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
Unknown
不适用
Study to Compare Pathologic Type, NIH and WHO Criteria,and Mechanism of GIST Malignant TransformationMethod of Differentiating Benignancy and Malignancy, Grading and Staging for GISTNCT03381053Shanghai Zhongshan Hospital3,000
已完成
不适用
Non-Interventional Retrospective Correlation Of Tumor Mutational Status To Clinical Benefit Of GIST Patients Treated With SunitinibGISTNCT01459757Pfizer322
Unknown
不适用
Role of Methylation Test Triage in HPV Positive WomenPrecancerous Cervical LesionNCT06366516Obstetrics & Gynecology Hospital of Fudan University10,000
Unknown
不适用
Comparison of Smart-Shear Wave Elastography and Transient ElastographyFibrosis, LiverNCT02569567Asan Medical Center105
已完成
不适用
Prospective Database of Gastrointestinal Stromal Cell Tumors (GISTs)Gastrointestinal Stromal Cell TumorsForegut Subepithelial LesionsNCT02147145Washington University School of Medicine187