Evaluation of the Long- Term Effects of Spiriva on Lung Function in COPD Patients
- Conditions
- Pulmonary Disease, Chronic Obstructive
- Registration Number
- NCT00144339
- Lead Sponsor
- Boehringer Ingelheim
- Brief Summary
The primary objective of this trial is to determine whether daily treatment with tiotropium (Spiriva®, Bromuro de Tiotropio®) inhalation capsule via HandiHaler® reduces the rate of decline in lung function over time in patients with COPD.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 5993
- Written informed consent.
- Male or female patients 40 years of age or older.
- Smoking history of at least 10 pack years.
- Diagnosis of COPD with post bronchodilator FEV1 less than or equal to 70% of predicted normal and FEV1<70% of FVC and on stable respiratory medication.
- Significant diseases other than COPD which in the opinion of the investigator may put the patient at risk or influence the patients ability to participate.
- Myocardial infarction in past 6 months.
- Unstable or life threatening arrhythmia in past year.
- Hospitalization for NYHA heart failure class III or IV in past year.
- Active tuberculosis.
- Asthma.
- Pulmonary resection.
- Malignancy treated with radiation or chemotherapy in past 5 years.
- Respiratory infection in 4 weeks prior to screening.
- Known hypersensitivity to anticholinergic drugs or components.
- Known moderate to severe renal impairment.
- Known narrow angle glaucoma.
- Significant symptomatic BPH or bladder neck obstruction.
- Need for oxygen therapy >12 hr/day.
- Use of oral corticosteroids at unstable doses or >10 mg/day.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Pre-bronchodilator Forced Expiratory Volume in One Second (FEV1) Rate of Decline From Day 30 to 4 Years From day 30 to 4 years Rate of decline of forced expiratory volume in one second (FEV1) measured before the use of bronchodilators. A negative rate of decline indicates decreasing FEV1 over time, while a positive value indicates increasing FEV1.
Post-bronchodilator Forced Expiratory Volume in One Second (FEV1) Rate of Decline From Day 30 to 4 Years From day 30 to 4 years Rate of decline of forced expiratory volume in one second (FEV1) measured after bronchodilation. A negative rate of decline indicates decreasing FEV1 over time, while a positive value indicates increasing FEV1.
- Secondary Outcome Measures
Name Time Method Estimated Pre-bronchodilator Forced Expiratory Volume in One Second (FEV1) at Month 24 Month 24 Estimated Post-bronchodilator Forced Expiratory Volume in One Second (FEV1) at Month 24 Month 24 Estimated Pre-bronchodilator Forced Expiratory Volume in One Second (FEV1) at Month 30 Month 30 Estimated Post-bronchodilator Forced Expiratory Volume in One Second (FEV1) at Month 30 Month 30 Pre-bronchodilator Forced Expiratory Volume in One Second (FEV1) Rate of Decline From Day 1 to 30 Days After Completion of Double Blinded Treatment Day 1 to 30 days after completion of double blinded treatment between Day 1 and 4 years plus 30 days. Rate of decline of forced expiratory volume in one second (FEV1) measured before the use of bronchodilators. A negative rate of decline indicates decreasing FEV1 over time, while a positive value indicates increasing FEV1
Pre-bronchodilator Forced Vital Capacity (FVC) Rate of Decline From Day 30 to 4 Years From day 30 to 4 years Rate of decline of forced vital capacity (FVC) measured before the use of bronchodilators. A negative rate of decline indicates decreasing FVC over time, while a positive value indicates increasing FVC
Time to First Exacerbation From Day 1 to 4 years Chronic obstructive pulmonary disease (COPD) exacerbation
Estimated Post-bronchodilator Forced Vital Capacity (FVC) at Month 12 Month 12 Estimated Pre-bronchodilator Forced Vital Capacity (FVC) at Month 18 Month 18 Estimated Pre-bronchodilator Forced Expiratory Volume in One Second (FEV1) at Month 36 Month 36 Post-bronchodilator Forced Expiratory Volume in One Second (FEV1) Rate of Decline From Day 1 to 30 Days After Completion of Double Blinded Treatment Day 1 to 30 days after completion of double blinded treatment between Day 1 and 4 years plus 30 days Rate of decline of forced expiratory volume in one second (FEV1) measured after the use of bronchodilators. A negative rate of decline indicates decreasing FEV1 over time, while a positive value indicates increasing FEV1
Post-bronchodilator Forced Vital Capacity (FVC) Rate of Decline From Day 30 to 4 Years From day 30 to 4 years Rate of decline of forced vital capacity (FVC) measured after bronchodilation. A negative rate of decline indicates decreasing FVC over time, while a positive value indicates increasing FVC
Pre-bronchodilator Slow Vital Capacity (SVC) Rate of Decline From Day 30 to 4 Years From day 30 to 4 years Rate of decline of slow vital capacity (SVC) measured before the use of bronchodilators. A negative rate of decline indicates decreasing SVC over time, while a positive value indicates increasing SVC
Post-bronchodilator Slow Vital Capacity (SVC) Rate of Decline From Day 30 to 4 Years From day 30 to 4 years Rate of decline of slow vital capacity (SVC) measured after bronchodilation. A negative rate of decline indicates decreasing SVC over time, while a positive value indicates increasing SVC
Rate of Decline of St George's Respiratory Questionnaire (SGRQ) Total Score From month 6 to 4 years SGRQ total score shows the impact of COPD on patient's health status, and expressed as a percentage of impairment with scale from 0 (best health status) to 100 (worst possible status). A negative rate of decline shows decreasing SGRQ total score (or improved health) over time, while a positive value shows increasing score (or worsen health).
Pre-bronchodilator Forced Vital Capacity (FVC) Rate of Decline From Day 1 to 30 Days After Completion of Double Blinded Treatment Day 1 to 30 days after completion of double blinded treatment between Day 1 and 4 years plus 30 days. Rate of decline of forced vital capacity (FVC) before bronchodilation. A negative rate of decline indicates decreasing FVC over time, while a positive value indicates increasing FVC
Post-bronchodilator Forced Vital Capacity (FVC) Rate of Decline From Day 1 to 30 Days After Completion of Double Blinded Treatment Day 1 to 30 days after completion of double blinded treatment between Day 1 and 4 years plus 30 days Rate of decline of forced vital capacity (FVC) after bronchodilation. A negative rate of decline indicates decreasing FVC over time, while a positive value indicates increasing FVC
Pre-bronchodilator Slow Vital Capacity (SVC) Rate of Decline From Day 1 to 30 Days After Completion of Double Blinded Treatment Day 1 to 30 days after completion of double blinded treatment between Day 1 and 4 years plus 30 days Rate of decline slow vital capacity (SVC) before bronchodilation. A negative rate of decline indicates decreasing SVC over time, while a positive value indicates increasing SVC
Post-bronchodilator Slow Vital Capacity (SVC) Rate of Decline From Day 1 to 30 Days After Completion of Double Blinded Treatment Day 1 to 30 days after completion of double blinded treatment between Day 1 and 4 years plus 30 days Rate of decline of slow vital capacity (SVC) after bronchodilation. A negative rate of decline indicates decreasing SVC over time, while a positive value indicates increasing SVC
Number of Chronic Obstructive Pulmonary Disease (COPD) Exacerbations Per Patient Year Day 1 to 4 years Number and Percentage of Patients With at Least One Chronic Obstructive Pulmonary Disease (COPD) Exacerbation Day 1 to 4 years Number of Exacerbation Days Per Patient Year Day 1 to 4 years Number of exacerbation days normalized by treatment exposure
Time to First COPD Exacerbation Leading to Hospitalization (for 25% Patients) Day 1 to 4 years Number and Percentage of Patients With at Least on COPD Exacerbation Leading to Hospitalization From Day 1 to 4 years Number of Exacerbation Leading to Hospitalization From Day 1 to 4 years Estimated number of exacerbations leading to hospitalizations per patient year
Days of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation Leading to Hospitalization From Day 1 to 4 years Number of days with chronic obstructive pulmonary disease (COPD) exacerbation leading to hospitalization (normalized by treatment exposure)
Estimated Pre-bronchodilator Forced Expiratory Volume in One Second (FEV1) at Month 1 Month 1 Estimated FEV1 before bronchodilator at Month 1
Estimated Post-bronchodilator Forced Expiratory Volume in One Second (FEV1) at Month 1 Month 1 Estimated forced expiratory volume in one second (FEV1) after bronchodilator at month 1
Estimated Pre-bronchodilator Forced Expiratory Volume in One Second (FEV1) at Month 6 Month 6 Estimated forced expiratory volume in one second (FEV1) before bronchodilator at month 6
Estimated Post-bronchodilator Forced Expiratory Volume in One Second (FEV1) at Month 6 Month 6 Estimated Pre-bronchodilator Forced Expiratory Volume in One Second (FEV1) at Month 12 Month 12 Estimated Post-bronchodilator Forced Expiratory Volume in One Second (FEV1) at Month 12 Month 12 Estimated Pre-bronchodilator Forced Expiratory Volume in One Second (FEV1) at Month 18 Month 18 Estimated Post-bronchodilator Forced Expiratory Volume in One Second (FEV1) at Month 18 Month 18 Estimated Post-bronchodilator Forced Expiratory Volume in One Second (FEV1) at Month 36 Month 36 Estimated Pre-bronchodilator Forced Expiratory Volume in One Second (FEV1) at Month 42 Month 42 Estimated Post-bronchodilator Forced Expiratory Volume in One Second (FEV1) at Month 42 Month 42 Estimated FEV1 after bronchodilator at Month 42
Estimated Pre-bronchodilator Forced Expiratory Volume in One Second (FEV1) at Month 48 Month 48 Estimated Post-bronchodilator Forced Expiratory Volume in One Second (FEV1) at Month 48 Month 48 Estimated Pre-bronchodilator Forced Vital Capacity (FVC) at Month 1 Month 1 Estimated Post-bronchodilator Forced Vital Capacity (FVC) at Month 1 Month 1 Estimated Pre-bronchodilator Forced Vital Capacity (FVC) at Month 6 Month 6 Estimated Post-bronchodilator Forced Vital Capacity (FVC) at Month 6 Month 6 Estimated Pre-bronchodilator Forced Vital Capacity (FVC) at Month 12 Month 12 Estimated Post-bronchodilator Forced Vital Capacity (FVC) at Month 18 Month 18 Estimated Pre-bronchodilator Forced Vital Capacity (FVC) at Month 24 Month 24 Estimated Post-bronchodilator Forced Vital Capacity (FVC) at Month 24 Month 24 Estimated Pre-bronchodilator Forced Vital Capacity (FVC) at Month 30 Month 30 Estimated Post-bronchodilator Forced Vital Capacity (FVC) at Month 30 Month 30 Estimated Pre-bronchodilator Forced Vital Capacity (FVC) at Month 36 Month 36 Estimated Post-bronchodilator Forced Vital Capacity (FVC) at Month 36 Month 36 Estimated Pre-bronchodilator Forced Vital Capacity (FVC) at Month 42 Month 42 Estimated Post-bronchodilator Forced Vital Capacity (FVC) at Month 42 Month 42 Estimated Pre-bronchodilator Forced Vital Capacity (FVC) at Month 48 Month 48 Estimated Post-bronchodilator Forced Vital Capacity (FVC) at Month 48 Month 48 Estimated Pre-bronchodilator Slow Vital Capacity (SVC) at Month 1 Month 1 Estimated Post-bronchodilator Slow Vital Capacity (SVC) at Month 12 Month 12 Estimated Pre-bronchodilator Slow Vital Capacity (SVC) at Month 6 Month 6 Estimated Pre-bronchodilator Slow Vital Capacity (SVC) at Month 30 Month 30 Estimated Post-bronchodilator Slow Vital Capacity (SVC) at Month 36 Month 36 Estimated St George's Respiratory Questionnaire (SGRQ) Total Score at Month 12 Month 12 * SGRQ total score summarizes the impact of COPD on overall patient's health status.
* Total scores are expressed as a percentage of overall impairment where 100 represents worst possible health status and 0 indicates best possible health status.
* The scale is continuous.
* Rate of decline shows the yearly change of SGRQ total score.Estimated Post-bronchodilator Slow Vital Capacity (SVC) at Month 1 Month 1 Estimated Pre-bronchodilator Slow Vital Capacity (SVC) at Month 24 Month 24 Estimated Post-bronchodilator Slow Vital Capacity (SVC) at Month 24 Month 24 Estimated Pre-bronchodilator Slow Vital Capacity (SVC) at Month 18 Month 18 Estimated Post-bronchodilator Slow Vital Capacity (SVC) at Month 6 Month 6 Estimated Pre-bronchodilator Slow Vital Capacity (SVC) at Month 12 Month 12 Estimated Post-bronchodilator Slow Vital Capacity (SVC) at Month 18 Month 18 Estimated Post-bronchodilator Slow Vital Capacity (SVC) at Month 30 Month 30 Estimated Pre-bronchodilator Slow Vital Capacity (SVC) at Month 36 Month 36 Estimated Pre-bronchodilator Slow Vital Capacity (SVC) at Month 42 Month 42 Estimated Post-bronchodilator Slow Vital Capacity (SVC) at Month 42 Month 42 Estimated Pre-bronchodilator Slow Vital Capacity (SVC) at Month 48 Month 48 Estimated Post-bronchodilator Slow Vital Capacity (SVC) at Month 48 Month 48 Estimated St George's Respiratory Questionnaire (SGRQ) Total Score at Month 6 Month 6 * SGRQ total score summarizes the impact of COPD on overall patient's health status.
* Total scores are expressed as a percentage of overall impairment where 100 represents worst possible health status and 0 indicates best possible health status.
* The scale is continuous.
* Rate of decline shows the yearly change of SGRQ total score.Estimated St George's Respiratory Questionnaire (SGRQ) Total Score at Month 18 Month 18 * SGRQ total score summarizes the impact of COPD on overall patient's health status.
* Total scores are expressed as a percentage of overall impairment where 100 represents worst possible health status and 0 indicates best possible health status.
* The scale is continuous.
* Rate of decline shows the yearly change of SGRQ total score.Estimated St George's Respiratory Questionnaire (SGRQ) Total Score at Month 24 Month 24 * SGRQ total score summarizes the impact of COPD on overall patient's health status.
* Total scores are expressed as a percentage of overall impairment where 100 represents worst possible health status and 0 indicates best possible health status.
* The scale is continuous.
* Rate of decline shows the yearly change of SGRQ total score.Estimated St George's Respiratory Questionnaire (SGRQ) Total Score at Month 30 Month 30 * SGRQ total score summarizes the impact of COPD on overall patient's health status.
* Total scores are expressed as a percentage of overall impairment where 100 represents worst possible health status and 0 indicates best possible health status.
* The scale is continuous.
* Rate of decline shows the yearly change of SGRQ total score.Estimated St George's Respiratory Questionnaire (SGRQ) Total Score at Month 36 Month 36 * SGRQ total score summarizes the impact of COPD on overall patient's health status.
* Total scores are expressed as a percentage of overall impairment where 100 represents worst possible health status and 0 indicates best possible health status.
* The scale is continuous.
* Rate of decline shows the yearly change of SGRQ total score.Estimated St George's Respiratory Questionnaire (SGRQ) Total Score at Month 42 Month 42 * SGRQ total score summarizes the impact of COPD on overall patient's health status.
* Total scores are expressed as a percentage of overall impairment where 100 represents worst possible health status and 0 indicates best possible health status.
* The scale is continuous.
* Rate of decline shows the yearly change of SGRQ total score.Estimated St George's Respiratory Questionnaire (SGRQ) Total Score at Month 48 Month 48 * SGRQ total score summarizes the impact of COPD on overall patient's health status.
* Total scores are expressed as a percentage of overall impairment where 100 represents worst possible health status and 0 indicates best possible health status.
* The scale is continuous.
* Rate of decline shows the yearly change of SGRQ total score.Number and Percentage of Participants With All Cause Death and Time to Event Analysis (On-treatment) Day 1 to completion of double blinded treatment plus 30 days between Day 1 and 4 years plus 30 days On-treatment defined as day 1 to completion of double blinded treatment plus 30 days
Number and Percentage of Participants With All Cause Death (Including Vital Status Follow-up, Cutoff at 1470 Days) Day 1 to day 1470 All cause mortality vital status information was followed-up after discontinuation; vital status information up to 1470 days after the start of treatment was used.
Number and Percentage of Participants With Lower Respiratory Death (On-treatment; Adjudicated Primary Cause) Day 1 to completion of double blinded treatment plus 30 days between Day 1 and 4 years plus 30 days The primary cause of death was adjudicated by an external committee prior to unblinding; on-treatment defined as day 1 to completion of double blinded treatment plus 30 days
Number and Percentage of Participants With a Lower Respiratory Death (Adjudicated; Including Vital Status Follow-up, Cutoff at 1470 Days) Day 1 to day 1470 The primary cause of death was adjudicated by an external committee prior to unblinding; vital status was information followed-up after discontinuation; vital status information up to 1470 days after the start of treatment was used
Trial Locations
- Locations (490)
205.235.3781 Boehringer Ingelheim Investigational Site
🇺🇸San Diego, California, United States
205.235.3782 Boehringer Ingelheim Investigational Site
🇺🇸Fredericksburg, Virginia, United States
205.235.3744 Boehringer Ingelheim Investigational Site
🇺🇸Danville, Virginia, United States
205.235.3792 Boehringer Ingelheim Investigational Site
🇺🇸Richmond, Virginia, United States
205.235.3718 Boehringer Ingelheim Investigational Site
🇺🇸Spokane, Washington, United States
205.235.3757 Boehringer Ingelheim Investigational Site
🇺🇸Olathe, Kansas, United States
205.235.3783 Boehringer Ingelheim Investigational Site
🇺🇸Wheat Ridge, Colorado, United States
205.235.3779 Boehringer Ingelheim Investigational Site
🇺🇸Anniston, Alabama, United States
205.235.3778 Boehringer Ingelheim Investigational Site
🇺🇸Escondito, California, United States
205.235.3786 Pulmonary and Critical Care Medicine
🇺🇸Orange, California, United States
205.235.3773 Boehringer Ingelheim Investigational Site
🇺🇸Los Angeles, California, United States
205.235.3802 Boehringer Ingelheim Investigational Site
🇺🇸Los Angeles, California, United States
205.235.3790 Boehringer Ingelheim Investigational Site
🇺🇸Atlanta, Georgia, United States
205.235.3810 Boehringer Ingelheim Investigational Site
🇺🇸Lakewood, California, United States
205.235.3717 Boehringer Ingelheim Investigational Site
🇺🇸San Diego, California, United States
205.235.3784 Boehringer Ingelheim Investigational Site
🇺🇸San Diego, California, United States
205.235.3812 Boehringer Ingelheim Investigational Site
🇺🇸Long Beach, California, United States
205.235.3795 Boehringer Ingelheim Investigational Site
🇺🇸Mobile, Alabama, United States
205.235.3811 Boehringer Ingelheim Investigational Site
🇺🇸Palo Alto, California, United States
205.235.3760 Boehringer Ingelheim Investigational Site
🇺🇸Sepulveda, California, United States
205.235.3804 Boehringer Ingelheim Investigational Site
🇺🇸Jasper, Alabama, United States
205.235.3758 Boehringer Ingelheim Investigational Site
🇺🇸Long Beach, California, United States
205.235.3800 Boehringer Ingelheim Investigational Site
🇺🇸Los Angeles, California, United States
205.235.513
🇧🇷São Paulo - SP, Brazil
205.235.3770 Boehringer Ingelheim Investigational Site
🇺🇸Carmichael, California, United States
205.235.3741 Boehringer Ingelheim Investigational Site
🇺🇸Rancho Mirage, California, United States
205.235.3719 Boehringer Ingelheim Investigational Site
🇺🇸Atlanta, Georgia, United States
205.235.3796 Boehringer Ingelheim Investigational Site
🇺🇸Albany, New York, United States
205.235.3815 Boehringer Ingelheim Investigational Site
🇺🇸WEst Haven, Connecticut, United States
205.235.3794 Boehringer Ingelheim Investigational Site
🇺🇸Stockbridge, Georgia, United States
205.235.3749 Boehringer Ingelheim Investigational Site
🇺🇸Dubuque, Iowa, United States
205.235.3711 Boehringer Ingelheim Investigational Site
🇺🇸Stockton, California, United States
205.235.3713 Boehringer Ingelheim Investigational Site
🇺🇸Normal, Illinois, United States
205.235.3768 Boehringer Ingelheim Investigational Site
🇺🇸Indianapolis, Indiana, United States
205.235.3816 Boehringer Ingelheim Investigational Site
🇺🇸Bronx, New York, United States
205.235.3791 Boehringer Ingelheim Investigational Site
🇺🇸Tulsa, Oklahoma, United States
205.235.3814 Boehringer Ingelheim Investigational Site
🇺🇸Kansas City, Missouri, United States
205.235.3731 Boehringer Ingelheim Investigational Site
🇺🇸Chapel Hill, North Carolina, United States
205.235.3734 Boehringer Ingelheim Investigational Site
🇺🇸Chesterfield, Missouri, United States
205.235.3701 Boehringer Ingelheim Investigational Site
🇺🇸Cleveland, Ohio, United States
205.235.3809 Boehringer Ingelheim Investigational Site
🇺🇸Livonia, Michigan, United States
205.235.3748 Boehringer Ingelheim Investigational Site
🇺🇸Mineola, New York, United States
205.235.3725 Boehringer Ingelheim Investigational Site
🇺🇸Hershey, Pennsylvania, United States
205.235.3807 Boehringer Ingelheim Investigational Site
🇺🇸Bayshore, New York, United States
205.235.3722 Boehringer Ingelheim Investigational Site
🇺🇸Rochester, New York, United States
205.235.3745 Boehringer Ingelheim Investigational Site
🇺🇸Elizabath City, North Carolina, United States
205.235.0804 Boehringer Ingelheim Investigational Site
🇩🇰Aalborg, Denmark
205.235.0821 Boehringer Ingelheim Investigational Site
🇩🇰Frederikshavn, Denmark
205.235.0811 Boehringer Ingelheim Investigational Site
🇩🇰Hillerød, Denmark
205.235.0833 Boehringer Ingelheim Investigational Site
🇩🇰Kalundborg, Denmark
205.235.0810 Boehringer Ingelheim Investigational Site
🇩🇰Næstved, Denmark
205.235.0831 Boehringer Ingelheim Investigational Site
🇩🇰Copenhagen, Denmark
205.235.0834 Boehringer Ingelheim Investigational Site
🇩🇰Hobro, Denmark
205.235.506
🇧🇷Porto Alegre - RS, Brazil
205.235.0803 Boehringer Ingelheim Investigational Site
🇩🇰Aarhus, Denmark
205.235.3609 Boehringer Ingelheim Investigational Site
🇬🇧Sheffield, United Kingdom
205.235.3601 Boehringer Ingelheim Investigational Site
🇬🇧Solihull, Birmingham, United Kingdom
205.235.0826 Boehringer Ingelheim Investigational Site
🇩🇰Aalborg SV, Denmark
205.235.0828 Boehringer Ingelheim Investigational Site
🇩🇰Copenhagen K, Denmark
205.235.0802 Boehringer Ingelheim Investigational Site
🇩🇰Copenhagen NV, Denmark
205.235.0832 Boehringer Ingelheim Investigational Site
🇩🇰Frederikssund, Denmark
205.235.0807 Boehringer Ingelheim Investigational Site
🇩🇰Fåborg, Denmark
205.235.0805 Boehringer Ingelheim Investigational Site
🇩🇰Hellerup, Denmark
205.235.0835 Boehringer Ingelheim Investigational Site
🇩🇰Hellerup, Denmark
205.235.0806 Boehringer Ingelheim Investigational Site
🇩🇰Holbæk, Denmark
205.235.0801 Boehringer Ingelheim Investigational Site
🇩🇰Hvidovre, Denmark
205.235.0824 Boehringer Ingelheim Investigational Site
🇩🇰Silkeborg, Denmark
205.235.0813 Boehringer Ingelheim Investigational Site
🇩🇰Skive, Denmark
205.235.0814 Boehringer Ingelheim Investigational Site
🇩🇰Holstebro, Denmark
205.235.0830 Boehringer Ingelheim Investigational Site
🇩🇰Kolding, Denmark
205.235.0819 Boehringer Ingelheim Investigational Site
🇩🇰Nykobing F., Denmark
205.235.0809 Boehringer Ingelheim Investigational Site
🇩🇰Odense C, Denmark
205.235.0822 Boehringer Ingelheim Investigational Site
🇩🇰Skive, Denmark
205.235.0820 Boehringer Ingelheim Investigational Site
🇩🇰Slagelse, Denmark
205.235.0808 Boehringer Ingelheim Investigational Site
🇩🇰Svendborg, Denmark
205.235.3785 Boehringer Ingelheim Investigational Site
🇺🇸Birmingham, Alabama, United States
205.235.3759 Boehringer Ingelheim Investigational Site
🇺🇸Phoenix, Arizona, United States
205.235.3732 Boehringer Ingelheim Investigational Site
🇺🇸Detroit, Michigan, United States
205.235.3752 Boehringer Ingelheim Investigational Site
🇺🇸Salt Lake City, Utah, United States
205.235.3751 Boehringer Ingelheim Investigational Site
🇺🇸Minneapolis, Minnesota, United States
205.235.3704 Boehringer Ingelheim Investigational Site
🇺🇸San Antonio, Texas, United States
205.235.3754 Boehringer Ingelheim Investigational Site
🇺🇸Minneapolis, Minnesota, United States
205.235.3736 Boehringer Ingelheim Investigational Site
🇺🇸Durham, North Carolina, United States
205.235.3764 Boehringer Ingelheim Investigational Site
🇺🇸Denver, Colorado, United States
205.235.3789 Boehringer Ingelheim Investigational Site
🇺🇸Rochester, Minnesota, United States
205.235.2409 Boehringer Ingelheim Investigational Site
🇵🇱Lodz, Poland
205.235.2503 Hospital Pulido Valente
🇵🇹Lisboa, Portugal
205.235.2602 Boehringer Ingelheim Investigational Site
🇷🇺Moscow, Russian Federation
205.235.3613 Boehringer Ingelheim Investigational Site
🇬🇧Chesterfield, United Kingdom
205.235.3616 Boehringer Ingelheim Investigational Site
🇬🇧Paisley, United Kingdom
205.235.1904 Boehringer Ingelheim Investigational Site
🇸🇬Singapore, Singapore
205.235.3762 Boehringer Ingelheim Investigational Site
🇺🇸Brandon, Florida, United States
205.235.3775 Boehringer Ingelheim Investigational Site
🇺🇸Panama City, Florida, United States
205.235.3756 Boehringer Ingelheim Investigational Site
🇺🇸Tampa, Florida, United States
205.235.3716 Boehringer Ingelheim Investigational Site
🇺🇸Augusta, Georgia, United States
205.235.3747 Boehringer Ingelheim Investigational Site
🇺🇸St. Louis, Missouri, United States
205.235.3788 Boehringer Ingelheim Investigational Site
🇺🇸Shreveport, Louisiana, United States
205.235.3729 Boehringer Ingelheim Investigational Site
🇺🇸Lexington, Kentucky, United States
205.235.3797 Boehringer Ingelheim Investigational Site
🇺🇸Cherry Hill, New Jersey, United States
205.235.3712 Boehringer Ingelheim Investigational Site
🇺🇸Winston-Salem, North Carolina, United States
205.235.3818 Boehringer Ingelheim Investigational Site
🇺🇸New York, New York, United States
205.235.3730 Boehringer Ingelheim Investigational Site
🇺🇸Burlington, North Carolina, United States
205.235.3765 Boehringer Ingelheim Investigational Site
🇺🇸Larchmont, New York, United States
205.235.3723 Boehringer Ingelheim Investigational Site
🇺🇸Cincinnati, Ohio, United States
205.235.3820 Boehringer Ingelheim Investigational Site
🇺🇸Portland, Oregon, United States
205.235.3817 Boehringer Ingelheim Investigational Site
🇺🇸Philadelphia, Pennsylvania, United States
205.235.3803 Boehringer Ingelheim Investigational Site
🇺🇸El Paso, Texas, United States
205.235.3715 Boehringer Ingelheim Investigational Site
🇺🇸Providence, Rhode Island, United States
205.235.3742 Boehringer Ingelheim Investigational Site
🇺🇸Houston, Texas, United States
205.235.3787 Boehringer Ingelheim Investigational Site
🇺🇸Houston, Texas, United States
205.235.3771 Boehringer Ingelheim Investigational Site
🇺🇸Lynchburg, Virginia, United States
205.235.3738 Boehringer Ingelheim Investigational Site
🇺🇸Richmond, Virginia, United States
205.235.3761 Boehringer Ingelheim Investigational Site
🇺🇸Salem, Virginia, United States
205.235.3780 Boehringer Ingelheim Investigational Site
🇺🇸La Crosse, Wisconsin, United States
205.235.101
🇦🇷Buenos Aires, Argentina
205.235.103 Hospital Alemán
🇦🇷Capital Federal, Argentina
205.235.101 Boehringer Ingelheim Investigational Site
🇦🇷Capital Federal, Argentina
205.235.105 Hospital General de Agudos José María Ramos Mejía
🇦🇷Capital Federal, Argentina
205.235.102 Instituto Cardiovascular de Rosario
🇦🇷Rosario, Argentina
205.235.108 Hospital General de Agudos Dr. Enrique Tornú
🇦🇷Capital Federal, Argentina
205.235.106 Hospital Cetrángolo
🇦🇷Vicente López, Argentina
205.235.0205 Boehringer Ingelheim Investigational Site
🇦🇺Bankstown, New South Wales, Australia
205.235.0202 Boehringer Ingelheim Investigational Site
🇦🇺Concord, New South Wales, Australia
205.235.0209 Boehringer Ingelheim Investigational Site
🇦🇺Westmead, New South Wales, Australia
205.235.0203 Boehringer Ingelheim Investigational Site
🇦🇺Redcliffe, Queensland, Australia
205.235.0201 Boehringer Ingelheim Investigational Site
🇦🇺Geelong, Victoria, Australia
205.235.0305 Boehringer Ingelheim Investigational Site
🇦🇹Innsbruck, Austria
205.235.0301 Boehringer Ingelheim Investigational Site
🇦🇹Wien, Austria
205.235.0302 Boehringer Ingelheim Investigational Site
🇦🇹Wien, Austria
205.235.0304 Boehringer Ingelheim Investigational Site
🇦🇹Leoben, Austria
205.235.0439 Boehringer Ingelheim Investigational Site
🇧🇪Anderlecht, Belgium
205.235.0434 Boehringer Ingelheim Investigational Site
🇧🇪Bruxelles, Belgium
205.235.0422 Boehringer Ingelheim Investigational Site
🇧🇪Dendermonde, Belgium
205.235.0424 Boehringer Ingelheim Investigational Site
🇧🇪Brussel, Belgium
205.235.0432 Boehringer Ingelheim Investigational Site
🇧🇪Bruxelles, Belgium
205.235.0414 Boehringer Ingelheim Investigational Site
🇧🇪Gent, Belgium
205.235.0405 Boehringer Ingelheim Investigational Site
🇧🇪Edegem, Belgium
205.235.0438 Boehringer Ingelheim Investigational Site
🇧🇪Mons, Belgium
205.235.0417 Boehringer Ingelheim Investigational Site
🇧🇪Herentals, Belgium
205.235.0418 U.Z. Gent
🇧🇪Gent, Belgium
205.235.0409 Boehringer Ingelheim Investigational Site
🇧🇪Kortrijk, Belgium
205.235.0402 Boehringer Ingelheim Investigational Site
🇧🇪Ieper, Belgium
205.235.0407 Boehringer Ingelheim Investigational Site
🇧🇪Leuven, Belgium
205.235.0406 Boehringer Ingelheim Investigational Site
🇧🇪Merksem, Belgium
205.235.0423 Boehringer Ingelheim Investigational Site
🇧🇪Oostende, Belgium
205.235.0437 Boehringer Ingelheim Investigational Site
🇧🇪Namur, Belgium
205.235.0420 Boehringer Ingelheim Investigational Site
🇧🇪Neerpelt, Belgium
205.235.0412 Boehringer Ingelheim Investigational Site
🇧🇪Turnhout, Belgium
205.235.510 Servico de Pneumologia
🇧🇷Florianópolis - SC, Brazil
205.235.507 Depto.de Medicina Interna-Servico de pneumologia
🇧🇷Porto Alegre - RS, Brazil
205.235.0702 Boehringer Ingelheim Investigational Site
🇨🇿Marianske Lazne, Czech Republic
205.235.0706 Boehringer Ingelheim Investigational Site
🇨🇿Praha 4, Czech Republic
205.235.0710 Boehringer Ingelheim Investigational Site
🇨🇿Prague 5, Czech Republic
205.235.0707 Boehringer Ingelheim Investigational Site
🇨🇿Praha 8, Czech Republic
205.235.0714 Boehringer Ingelheim Investigational Site
🇨🇿Tabor, Czech Republic
205.235.0816 Boehringer Ingelheim Investigational Site
🇩🇰Helsingor, Denmark
205.235.0815 Boehringer Ingelheim Investigational Site
🇩🇰Randers, Denmark
205.235.0827 Boehringer Ingelheim Investigational Site
🇩🇰Værløse, Denmark
205.235.0903 Boehringer Ingelheim Investigational Site
🇫🇮Helsinki, Finland
205.235.0904 Boehringer Ingelheim Investigational Site
🇫🇮Lahti, Finland
205.235.0902 Boehringer Ingelheim Investigational Site
🇫🇮Pori, Finland
205.235.1004 Clinique Toulouse Lautrec
🇫🇷Albi cedex 9, France
205.235.1007 Cabinet Médical
🇫🇷Albi, France
205.235.1015 Centre Hospitalier
🇫🇷Barbezieux St Hilaire, France
205.235.1024 Cabinet Médical
🇫🇷Chamalières, France
205.235.1006 Centre Hospitalier de Chauny
🇫🇷Chauny cedex, France
205.235.1005 Polyclinique
🇫🇷Cholet, France
205.235.1013 Cabinet Médical
🇫🇷La Teste, France
205.235.1023 Cabinet Médical
🇫🇷Montauban, France
205.235.1001 Hôpital Bichat
🇫🇷Paris, France
205.235.1002 Cabinet médical
🇫🇷Nice, France
205.235.1021 Clinique Pasteur
🇫🇷Toulouse, France
205.235.1009 Centre Hospitalier de Bigorre
🇫🇷Tarbes cedex 9, France
205.235.1114 Boehringer Ingelheim Investigational Site
🇩🇪Berlin, Germany
205.235.1113 Boehringer Ingelheim Investigational Site
🇩🇪Berlin, Germany
205.235.1103 Boehringer Ingelheim Investigational Site
🇩🇪Brake, Germany
205.235.1115 Boehringer Ingelheim Investigational Site
🇩🇪Hannover, Germany
205.235.1108 Boehringer Ingelheim Investigational Site
🇩🇪Lörrach, Germany
205.235.1106 Boehringer Ingelheim Investigational Site
🇩🇪München, Germany
205.235.1110 Boehringer Ingelheim Investigational Site
🇩🇪München, Germany
205.235.1101 Boehringer Ingelheim Investigational Site
🇩🇪Ulm, Germany
205.235.1107 Boehringer Ingelheim Investigational Site
🇩🇪Weyhe, Germany
205.235.1112 Boehringer Ingelheim Investigational Site
🇩🇪Wiesloch, Germany
205.235.1201 Boehringer Ingelheim Investigational Site
🇬🇷Heraklion, Greece
205.235.1202 8th Pulmonology Clinic "Sotiria" Athens Chest Hospital
🇬🇷Athens, Greece
205.235.1203 Boehringer Ingelheim Investigational Site
🇬🇷Athens, Greece
205.235.1211 Boehringer Ingelheim Investigational Site
🇬🇷Kavala, Greece
205.235.1209 Boehringer Ingelheim Investigational Site
🇬🇷Patra, Greece
205.235.1204 Boehringer Ingelheim Investigational Site
🇬🇷Larissa, Greece
205.235.1206 Boehringer Ingelheim Investigational Site
🇬🇷Thessaloniki, Greece
205.235.1205 Boehringer Ingelheim Investigational Site
🇬🇷Thessaloniki, Greece
205.235.1210 Boehringer Ingelheim Investigational Site
🇬🇷Patra, Greece
205.235.1207 Boehringer Ingelheim Investigational Site
🇬🇷Thessaloniki, Greece
205.235.1401 Boehringer Ingelheim Investigational Site
🇭🇰Hong Kong, Hong Kong
205.235.1308 Boehringer Ingelheim Investigational Site
🇭🇺Budapest, Hungary
205.235.1310 Boehringer Ingelheim Investigational Site
🇭🇺Budapest, Hungary
205.235.1311 Boehringer Ingelheim Investigational Site
🇭🇺Budapest, Hungary
205.235.1309 Boehringer Ingelheim Investigational Site
🇭🇺Budapest, Hungary
205.235.1318 Boehringer Ingelheim Investigational Site
🇭🇺Debrecen, Hungary
205.235.1314 Boehringer Ingelheim Investigational Site
🇭🇺Deszk, Hungary
205.235.1304 Boehringer Ingelheim Investigational Site
🇭🇺Miskolc, Hungary
205.235.1306 Boehringer Ingelheim Investigational Site
🇭🇺Erd, Hungary
205.235.1320 Boehringer Ingelheim Investigational Site
🇭🇺Gyula, Hungary
205.235.1317 Boehringer Ingelheim Investigational Site
🇭🇺Mosonmagyarovar, Hungary
205.235.1301 Boehringer Ingelheim Investigational Site
🇭🇺Pecs, Hungary
205.235.1313 Boehringer Ingelheim Investigational Site
🇭🇺Solymar, Hungary
205.235.1319 Boehringer Ingelheim Investigational Site
🇭🇺Szombathely, Hungary
205.235.1316 Boehringer Ingelheim Investigational Site
🇭🇺Törökbalint, Hungary
205.235.1302 Boehringer Ingelheim Investigational Site
🇭🇺Tatabanya, Hungary
205.235.1505 Boehringer Ingelheim Investigational Site
🇮🇪Dublin 15, Ireland
205.235.1312 Boehringer Ingelheim Investigational Site
🇭🇺Veszprem, Hungary
205.235.1503 Boehringer Ingelheim Investigational Site
🇮🇪Dublin 4, Ireland
205.235.1618 Ospedale Bellaria
🇮🇹Bologna, Italy
205.235.1501 Boehringer Ingelheim Investigational Site
🇮🇪Dublin 9, Ireland
205.235.1631 A. O. SS. Antonio e Biagio e Arrigo
🇮🇹Alessandria, Italy
205.235.1613 A. O. S. Giuseppe Moscati
🇮🇹Avellino, Italy
205.235.1649 Ospedale di Circolo di Busto Arsizio
🇮🇹Busto Arsizio (VA), Italy
205.235.1645 Ospedale Civile "Zappatoni"
🇮🇹CASSANO D'ADDA (Milano), Italy
205.235.1635 P. O. Roberto Binaghi
🇮🇹Cagliari, Italy
205.235.1623 A. O. di Carrara
🇮🇹Carrara (Massa), Italy
205.235.1617 Ospedale S. Camillo De Lellis
🇮🇹Chieti, Italy
205.235.1622 A. O. S. Anna
🇮🇹Ferrara, Italy
205.235.1612 A. O. S. Antonio Abate
🇮🇹Erice (Trapani), Italy
205.235.1647 A. O. Careggi
🇮🇹Firenze, Italy
205.235.1646 A. O. di Careggi
🇮🇹Firenze, Italy
205.235.1634 P. O. Luigi Sacco
🇮🇹Milano, Italy
205.235.1624 Ospedale di Macerata
🇮🇹Macerata, Italy
205.235.1629 A. O. S. Luigi Gonzaga
🇮🇹Orbassano (Torino), Italy
205.235.1615 Ospedale S. Martino
🇮🇹Genova, Italy
205.235.1604 P. O. R. Silvestrini
🇮🇹Perugia, Italy
205.235.1643 A. O. Santa Maria degli Angeli
🇮🇹Pordenone, Italy
205.235.1601 Presidio Ospedaliero di Cisanello
🇮🇹Pisa, Italy
205.235.1614 Ospedale Misericordia e Dolce
🇮🇹Prato, Italy
205.235.1608 ASL 1 di Sassari
🇮🇹Sassari, Italy
205.235.1607 Università degli Studi di Sassari
🇮🇹Sassari, Italy
205.235.1606 ASL 4 di Terni
🇮🇹Terni, Italy
205.235.1633 A. O. Umberto I
🇮🇹Torrette di Ancona (Ancona), Italy
205.235.1632 ASL 4 - Distretto 2
🇮🇹Torino, Italy
205.235.1602 Ospedale di Voghera
🇮🇹Voghera (Pavia), Italy
205.235.1705 Kameda Medical Center
🇯🇵Kamogawa, Chiba, Japan
205.235.1713 Komaki City Hospital
🇯🇵Komaki, Aichi, Japan
205.235.1712 Kurume University Hospital
🇯🇵Kurume, Fukuoka, Japan
205.235.1710 Osaka City University Hospital
🇯🇵Osaka, Osaka, Japan
205.235.1711 Kinki University Hospital
🇯🇵Osakasayama, Osaka, Japan
205.235.1708 Shinshu University
🇯🇵Matsumoto, Nagano, Japan
205.235.1702 Iwate Medical University Hospital
🇯🇵Morioka, Iwate, Japan
205.235.1704 Hiraka General Hospital
🇯🇵Yokote, Akita, Japan
205.235.1703 Tohoku University Hospital
🇯🇵Sendai, Miyagi, Japan
205.235.1709 Tosei General Hospital
🇯🇵Seto, Aichi, Japan
205.235.1701 Hokkaido University
🇯🇵Sapporo, Hokkaido, Japan
205.235.1801 Boehringer Ingelheim Investigational Site
🇱🇹Kaunas, Lithuania
205.235.1802 Boehringer Ingelheim Investigational Site
🇱🇹Kaunas, Lithuania
205.235.1803 Boehringer Ingelheim Investigational Site
🇱🇹Vilnius, Lithuania
205.235.1903 Boehringer Ingelheim Investigational Site
🇲🇾Kuala Lumpur, Malaysia
205.235.1902 Boehringer Ingelheim Investigational Site
🇲🇾Kuala Lumpur, Malaysia
205.235.2005
🇲🇽Ciudad de Mexico, Mexico
205.235.2004 Edif. Dr. Rodrigo F. Barragan, P.B.
🇲🇽Col. Mitras Centro, Monterrey, N.L., Mexico
205.235.2006 Tlalpan 4000, Pabellón 5, EPOC
🇲🇽Ciudad de Mexico, Mexico
205.235.2002
🇲🇽Guadalajara, Jal., Mexico
205.235.2010 Depto. De Ivestigación
🇲🇽Toluca, Mexico
205.235.2107 Poli Longziekten
🇳🇱Delft, Netherlands
205.235.2104 Poli longziekten
🇳🇱Eindhoven, Netherlands
205.235.2106 Lokatie Dordwijk
🇳🇱Dordrecht, Netherlands
205.235.2102 Martini Ziekenhuis Groningen
🇳🇱Groningen, Netherlands
205.235.2112 Poli Longziekten
🇳🇱Harderwijk, Netherlands
205.235.2101 Atrium medisch centrum
🇳🇱Heerlen, Netherlands
205.235.2114 Poli Longziekten
🇳🇱Hengelo, Netherlands
205.235.2108 Poli Longziekten
🇳🇱Leeuwarden, Netherlands
205.235.0211 Boehringer Ingelheim Investigational Site
🇳🇿Auckland, New Zealand
205.235.2109 Poli Longziekten
🇳🇱Rotterdam, Netherlands
205.235.2111 Antonius Ziekenhuis
🇳🇱Sneek, Netherlands
205.235.0212 Boehringer Ingelheim Investigational Site
🇳🇿Christchurch, New Zealand, New Zealand
205.235.2202 Boehringer Ingelheim Investigational Site
🇳🇴Arendal, Norway
205.235.2204 Boehringer Ingelheim Investigational Site
🇳🇴Straume, Norway
205.235.2201 Boehringer Ingelheim Investigational Site
🇳🇴Fredrikstad, Norway
205.235.2301 Philippine General Hospital
🇵🇭Manila, Philippines
205.235.2302 Philippine Heart Center
🇵🇭Quezon City, Philippines
205.235.2305 University of Santo Tomas Hospital
🇵🇭Manila, Philippines
205.235.2303 Veterans Memorial Medical Center
🇵🇭Quezon City, Philippines
205.235.2304 Lung Center of the Philippines
🇵🇭Quezon City, Philippines
205.235.2410 Boehringer Ingelheim Investigational Site
🇵🇱Gdansk, Poland
205.235.2403 Boehringer Ingelheim Investigational Site
🇵🇱Warsaw, Poland
205.235.2401 Boehringer Ingelheim Investigational Site
🇵🇱Warsaw, Poland
205.235.2402 Boehringer Ingelheim Investigational Site
🇵🇱Warsaw, Poland
205.235.2407 Boehringer Ingelheim Investigational Site
🇵🇱Katowice, Poland
205.235.2404 Boehringer Ingelheim Investigational Site
🇵🇱Wroclaw, Poland
205.235.2504 Centro Hospitalar de Coimbra
🇵🇹Coimbra, Portugal
205.235.2406 Boehringer Ingelheim Investigational Site
🇵🇱Zabrze, Poland
205.235.2505 Hospital de Santa Marta
🇵🇹Lisboa, Portugal
205.235.2501 Hospital de São João
🇵🇹Porto, Portugal
205.235.2502 Centro Hospitalar de Vila Nova de Gaia
🇵🇹Vila Nova de Gaia, Portugal
205.235.2603 Boehringer Ingelheim Investigational Site
🇷🇺Moscow, Russian Federation
205.235.2601 Boehringer Ingelheim Investigational Site
🇷🇺Moscow, Russian Federation
205.235.2605 Boehringer Ingelheim Investigational Site
🇷🇺Moscow, Russian Federation
205.235.2604 Boehringer Ingelheim Investigational Site
🇷🇺St. Petersburg, Russian Federation
205.235.1905 Boehringer Ingelheim Investigational Site
🇸🇬Singapore, Singapore
205.235.1906 Boehringer Ingelheim Investigational Site
🇸🇬Singapore, Singapore
205.235.2701 Boehringer Ingelheim Investigational Site
🇸🇰Bratislava, Slovakia
205.235.2704 Boehringer Ingelheim Investigational Site
🇸🇰Poprad, Slovakia
205.235.2705 Boehringer Ingelheim Investigational Site
🇸🇰Topolcany, Slovakia
205.235.2801 Boehringer Ingelheim Investigational Site
🇸🇮Golnik, Slovenia
205.235.2805 Boehringer Ingelheim Investigational Site
🇸🇮Kamnik, Slovenia
205.235.2803 Boehringer Ingelheim Investigational Site
🇸🇮Ljubljana, Slovenia
205.235.2804 Boehringer Ingelheim Investigational Site
🇸🇮Topolsica, Slovenia
205.235.2908
🇿🇦Bloemfontein, South Africa
205.235.2910
🇿🇦Cape Town, South Africa
205.235.2912
🇿🇦Cape Town, South Africa
205.235.2911
🇿🇦Durban, South Africa
205.235.2902
🇿🇦George, South Africa
205.235.2905
🇿🇦Paarl, South Africa
205.235.2901 Boehringer Ingelheim Investigational Site
🇿🇦Pretoria, South Africa
205.235.2906
🇿🇦Somerset West, South Africa
205.235.2903
🇿🇦Vanderbijlpark, South Africa
205.235.3014 Complejo Hospitalario Juan Canalejo
🇪🇸A Coruña, Spain
205.235.3026 Hospital General Universitario de Alicante
🇪🇸Alicante, Spain
205.235.3011 Complejo Hospitalario Infanta Cristina
🇪🇸Badajoz, Spain
205.235.3006 Hospital Germans Trias i Pujol
🇪🇸Badalona (Barcelona), Spain
205.235.3022 Hospital de Cruces
🇪🇸Barakaldo (Bilbao), Spain
205.235.3003 Hospital Clínic i Provincial de Barcelona
🇪🇸Barcelona, Spain
205.235.3023 Hospital Dr. Josep Trueta
🇪🇸Girona, Spain
205.235.3008 Hospital Vall d'Hebrón
🇪🇸Barcelona, Spain
205.235.3004 Hospital General Universitario de Guadalajara
🇪🇸Guadalajara, Spain
205.235.3005 Hospital General San Jorge de Huesca
🇪🇸Huesca, Spain
205.235.3021 Hospital de Jerez de la Frontera
🇪🇸Jerez de la Frontera, Spain
205.235.3010 Hospital Severo Ochoa
🇪🇸Leganés, Madrid, Spain
205.235.3009 Hospital Clínico San Carlos
🇪🇸Madrid, Spain
205.235.3013 Clínica Puerta de Hierro
🇪🇸Madrid, Spain
205.235.3020 Hospital Universitario La Paz
🇪🇸Madrid, Spain
205.235.3017 Hospital Ramón y Cajal
🇪🇸Madrid, Spain
205.235.3028 Hospital Universitario de la Princesa
🇪🇸Madrid, Spain
205.235.3031 Hospital Gregorio Marañón
🇪🇸Madrid, Spain
205.235.3036 Hospital 12 de Octubre
🇪🇸Madrid, Spain
205.235.3033 Hospital General Carlos Haya
🇪🇸Málaga, Spain
205.235.3027 Complejo Asistencial Son Dureta
🇪🇸Palma de Mallorca, Spain
205.235.3024 Hospital de Montecelo
🇪🇸Pontevedra, Spain
205.235.3037 Hsopital Universitario Ntra. Sra. de la Candelaria
🇪🇸Santa Cruz de Tenerife, Spain
205.235.3016 Hospital Universitari de Sant Joan
🇪🇸Reus (Tarragona), Spain
205.235.3015 Corporació Sanitaria Parc Taulí de Sabadell
🇪🇸Sabadell (Barcelona), Spain
205.235.3039 Hospital Universitario Marqués de Valdecilla
🇪🇸Santander, Spain
205.235.3019 Hospital Vírgen de la Macarena
🇪🇸Sevilla, Spain
205.235.3001 Hospital Mutua Terrassa
🇪🇸Terrassa (Barcelona), Spain
205.235.3035 Hospital Universitario Vírgen del Rocío
🇪🇸Sevilla, Spain
205.235.3002 Hospital Clínico Universitario de Valencia
🇪🇸Valencia, Spain
205.235.3025 Hospital Universitario Dr. Peset
🇪🇸Valencia, Spain
205.235.3032 Hospital Arnau de Vilanova
🇪🇸Valencia, Spain
205.235.3034 Hospital La Fe
🇪🇸Valencia, Spain
205.235.3030 Hospital Miguel Servet
🇪🇸Zaragoza, Spain
205.235.3018 Complejo Hospitalario Xeral - Cíes
🇪🇸Vigo, Spain
205.235.3038 Hospital Clínico Lozano Blesa
🇪🇸Zaragoza, Spain
205.235.3202 Boehringer Ingelheim Investigational Site
🇨🇭Basel, Switzerland
205.235.3203 Universitätsspital Basel
🇨🇭Basel, Switzerland
205.235.3204 Boehringer Ingelheim Investigational Site
🇨🇭Faltigberg, Switzerland
205.235.3205 Boehringer Ingelheim Investigational Site
🇨🇭Lugano, Switzerland
205.235.3206 Boehringer Ingelheim Investigational Site
🇨🇭Montana, Switzerland
205.235.3208 Boehringer Ingelheim Investigational Site
🇨🇭Winterthur, Switzerland
205.235.3201 Boehringer Ingelheim Investigational Site
🇨🇭Zürich, Switzerland
205.235.3303 Boehringer Ingelheim Investigational Site
🇨🇳Taipei, Taiwan
205.235.3404 Boehringer Ingelheim Investigational Site
🇹🇭Bangkok, Thailand
205.235.3401 Boehringer Ingelheim Investigational Site
🇹🇭Chiang Mai, Thailand
205.235.3502 Yedikule Gögüs Hastaliklari Hastanesi
🇹🇷Istanbul, Turkey
205.235.3405 Boehringer Ingelheim Investigational Site
🇹🇭Khon Kaen, Thailand
205.235.3506 Hacettepe Tip Fakultesi
🇹🇷Ankara, Turkey
205.235.3507 Ankara SSK Diskapi Egitim Hastanesi
🇹🇷Ankara, Turkey
205.235.3501 Istanbul Universitesi Cerrahpasa Tip Fakultesi
🇹🇷Istanbul, Turkey
205.235.3511 Osmangazi Universitesi Tip Fakültesi
🇹🇷Eskisehir, Turkey
205.235.3505 Istanbul Universitesi Tip Fakültesi
🇹🇷Istanbul, Turkey
205.235.3503 Tophanelioglu Cad. No: 13/15
🇹🇷Istanbul, Turkey
205.235.3615 Boehringer Ingelheim Investigational Site
🇬🇧Aberdeen, United Kingdom
205.235.3611 Boehringer Ingelheim Investigational Site
🇬🇧Chertsey, United Kingdom
205.235.3608 Boehringer Ingelheim Investigational Site
🇬🇧Cottingham, Hull, United Kingdom
205.235.3605 Boehringer Ingelheim Investigational Site
🇬🇧Exeter, United Kingdom
205.235.3602 Boehringer Ingelheim Investigational Site
🇬🇧Glasgow, United Kingdom
205.235.3610 Boehringer Ingelheim Investigational Site
🇬🇧Leeds, United Kingdom
205.235.3607 Boehringer Ingelheim Investigational Site
🇬🇧Leicester, United Kingdom
205.235.3612 Boehringer Ingelheim Investigational Site
🇬🇧Nottingham, United Kingdom
205.235.3604 Boehringer Ingelheim Investigational Site
🇬🇧Middleton, United Kingdom
205.235.3603 Boehringer Ingelheim Investigational Site
🇬🇧Plymouth, United Kingdom
205.235.3614 Boehringer Ingelheim Investigational Site
🇬🇧Penarth, United Kingdom
205.235.3793 Boehringer Ingelheim Investigational Site
🇺🇸Norwalk, Connecticut, United States
205.235.3727 Boehringer Ingelheim Investigational Site
🇺🇸Hartford, Connecticut, United States
205.235.3739 Boehringer Ingelheim Investigational Site
🇺🇸West Palm Beach, Florida, United States
205.235.3703 Boehringer Ingelheim Investigational Site
🇺🇸Melbourne, Florida, United States
205.235.3706 Boehringer Ingelheim Investigational Site
🇺🇸Bay Pines, Florida, United States
205.235.3707 Boehringer Ingelheim Investigational Site
🇺🇸Largo, Florida, United States
205.235.3737 Boehringer Ingelheim Investigational Site
🇺🇸Metairie, Louisiana, United States
205.235.3806 Boehringer Ingelheim Investigational Site
🇺🇸Baltimore, Maryland, United States
205.235.3763 Boehringer Ingelheim Investigational Site
🇺🇸Lebanon, New Hampshire, United States
205.235.3808 Boehringer Ingelheim Investigational Site
🇺🇸Hartford, Connecticut, United States
205.235.3724 Boehringer Ingelheim Investigational Site
🇺🇸Coeur d'Alene, Idaho, United States
205.235.3726 354 Birnie Ave
🇺🇸Springfield, Massachusetts, United States
205.235.3721 Boehringer Ingelheim Investigational Site
🇺🇸Boston, Massachusetts, United States
205.235.0421 Boehringer Ingelheim Investigational Site
🇧🇪Brugge, Belgium
205.235.0413 Boehringer Ingelheim Investigational Site
🇧🇪Turnhout, Belgium
205.235.501
🇧🇷Porto Alegre - RS, Brazil
205.235.0725 University Hospital Brno
🇨🇿Brno, Czech Republic
205.235.0722 Hospital Kromeriz
🇨🇿Kromeriz, Czech Republic
205.235.0724 District Hospital Kyjov
🇨🇿Kyjov, Czech Republic
205.235.0708 Boehringer Ingelheim Investigational Site
🇨🇿Praha 5 - Nove Butovice, Czech Republic
205.235.0721 Office of Pulmonary Diseases
🇨🇿Pribor, Czech Republic
205.235.0303 Boehringer Ingelheim Investigational Site
🇦🇹Graz, Austria
205.235.3743 Boehringer Ingelheim Investigational Site
🇺🇸Sarasota, Florida, United States
205.235.104 Hospital de Clinicas José de San Martín
🇦🇷Capital Federal, Argentina
205.235.0435 Boehringer Ingelheim Investigational Site
🇧🇪Nobressart (ATTERT), Belgium
205.235.511 Departamento de Pneumologia
🇧🇷Salvador - BA, Brazil
205.235.515 Lar Escola São Francisco / Setor de Pneumologia
🇧🇷São Paulo - SP, Brazil
205.235.0718 Clinic of Functional Diagnostics and Rehabilitation
🇨🇿Brno, Czech Republic
205.235.0726 Private Office of Pulmonary Diseases
🇨🇿Jaromer, Czech Republic
205.235.0703 Boehringer Ingelheim Investigational Site
🇨🇿Plzen, Czech Republic
205.235.0709 Boehringer Ingelheim Investigational Site
🇨🇿Praha 4, Czech Republic
205.235.1025 Centre Médical Erdre Saint Augustin
🇫🇷Nantes, France
205.235.1648 Ospedale "S. Maria di Collemaggio"
🇮🇹L'Aquila, Italy
205.235.2115 Poli Longziekten
🇳🇱Heerenveen, Netherlands
205.235.107 Policlínica Bancaria
🇦🇷Capital Federal, Argentina
205.235.110 Hospital Privado - Centro Médico de Córdoba S.A.
🇦🇷Parque Velez Sarlfield, Argentina
205.235.0433 Boehringer Ingelheim Investigational Site
🇧🇪Tournai, Belgium
205.235.505 Dep.Medicina Especializada (DEMESP)
🇧🇷Rio de Janeiro - RJ, Brazil
205.235.512
🇧🇷São Paulo - SP, Brazil
205.235.0712 Boehringer Ingelheim Investigational Site
🇨🇿Benesov, Czech Republic
205.235.0705 Boehringer Ingelheim Investigational Site
🇨🇿Jablonec nad Nisou, Czech Republic
205.235.0701 Boehringer Ingelheim Investigational Site
🇨🇿Plzen, Czech Republic
205.235.0715 Boehringer Ingelheim Investigational Site
🇨🇿Praha 5, Czech Republic
205.235.0723 Office of Pulmonary and Respiratory Diseases
🇨🇿Prerov, Czech Republic
205.235.1012 Cabinet Médical
🇫🇷Bourges, France
205.235.1109 Boehringer Ingelheim Investigational Site
🇩🇪Kaufbeuren, Germany
205.235.1102 Boehringer Ingelheim Investigational Site
🇩🇪Lübeck, Germany
205.235.3813 Boehringer Ingelheim Investigational Site
🇺🇸Ann Arbor, Michigan, United States
205.235.3799 Boehringer Ingelheim Investigational Site
🇺🇸Summit, New Jersey, United States
205.235.1303 Boehringer Ingelheim Investigational Site
🇭🇺Budapest, Hungary
205.235.109 Hospital Muñiz
🇦🇷Capital Federal, Argentina
205.235.0440 Boehringer Ingelheim Investigational Site
🇧🇪Luxembourg, Belgium
205.235.0404 Boehringer Ingelheim Investigational Site
🇧🇪Middelheim, Belgium
205.235.508
🇧🇷Juiz de Fora - MG, Brazil
205.235.503
🇧🇷Porto Alegre - RS, Brazil
205.235.0720 Office of Pulmonology and Respiratory Diseases
🇨🇿Cesky Tesin, Czech Republic
205.235.0717 Pulmonary Clinic
🇨🇿Hradec Kralove, Czech Republic
205.235.0704 Boehringer Ingelheim Investigational Site
🇨🇿Lovosice, Czech Republic
205.235.0713 Boehringer Ingelheim Investigational Site
🇨🇿Strakonice, Czech Republic
205.235.0716 Boehringer Ingelheim Investigational Site
🇨🇿Znojmo, Czech Republic
205.235.0905 Boehringer Ingelheim Investigational Site
🇫🇮Kotka, Finland
205.235.1016 Cabinet Médical
🇫🇷Provins, France
205.235.1104 Boehringer Ingelheim Investigational Site
🇩🇪Bruchsal, Germany
205.235.1640 P. O. Cà Foncello
🇮🇹Treviso, Italy
205.235.2003
🇲🇽Zapopan, jalisco, Mexico
205.235.2105 Lokatie De Lichtenberg
🇳🇱Amersfoort, Netherlands
205.235.0429 Boehringer Ingelheim Investigational Site
🇧🇪Baudour, Belgium
205.235.0403 Boehringer Ingelheim Investigational Site
🇧🇪Menen, Belgium
205.235.0428 Boehringer Ingelheim Investigational Site
🇧🇪Yvoir, Belgium
205.235.502
🇧🇷Rio de Janeiro - RJ, Brazil
205.235.504 ANEXO 2-Laboratório de Funcao Pulmonar
🇧🇷Santo André - SP, Brazil
205.235.514 Unidade de Coracao e Pulmao do Dto. de Medicina
🇧🇷São Paulo - SP, Brazil
205.235.0711 Boehringer Ingelheim Investigational Site
🇨🇿Beroun, Czech Republic
205.235.1020 Cabinet Médical
🇫🇷Marseille, France
205.235.1019 Cabinet Médical
🇫🇷Strasbourg, France
205.235.1105 Boehringer Ingelheim Investigational Site
🇩🇪Braunschweig, Germany
205.235.1603 P. O. di Gubbio
🇮🇹Gubbio (Perugia), Italy
205.235.2110 Poli Longziekten
🇳🇱Almelo, Netherlands
205.235.2405 Boehringer Ingelheim Investigational Site
🇵🇱Lodz, Poland
205.235.2702 Boehringer Ingelheim Investigational Site
🇸🇰Bratislava, Slovakia
205.235.2904
🇿🇦Durban, South Africa
205.235.0207 Boehringer Ingelheim Investigational Site
🇦🇺Port Lincoln, South Australia, Australia
205.235.0206 Boehringer Ingelheim Investigational Site
🇦🇺Box Hill, Victoria, Australia
205.235.0719 Office of Pulmonology and Respiratory Diseases
🇨🇿Usti nad Orlici, Czech Republic
205.235.0901 Boehringer Ingelheim Investigational Site
🇫🇮Jyväskylä, Finland
205.235.1315 Boehringer Ingelheim Investigational Site
🇭🇺Farkasgyepü, Hungary
205.235.1307 Boehringer Ingelheim Investigational Site
🇭🇺Kiskunhalas, Hungary
205.235.1305 Boehringer Ingelheim Investigational Site
🇭🇺Sopron, Hungary
205.235.1639 Ospedale Maggiore
🇮🇹Modica (Ragusa), Italy
205.235.1706 Juntendo University Hospital
🇯🇵Bunkyo-ku, Tokyo, Japan
205.235.1901 Boehringer Ingelheim Investigational Site
🇲🇾Kuala Lumpur, Malaysia
205.235.2205 Boehringer Ingelheim Investigational Site
🇳🇴Sandvika, Norway
205.235.2408 Boehringer Ingelheim Investigational Site
🇵🇱Krakow, Poland
205.235.1619 A. O. Fratelli Crobu
🇮🇹Iglesias (Cagliari), Italy
205.235.2009
🇲🇽Puebla, Mexico
205.235.2703 Boehringer Ingelheim Investigational Site
🇸🇰Martin, Slovakia
205.235.2802 Boehringer Ingelheim Investigational Site
🇸🇮Golnik, Slovenia
205.235.3402 Boehringer Ingelheim Investigational Site
🇹🇭Bangkok, Thailand
205.235.3403 Boehringer Ingelheim Investigational Site
🇹🇭Bangkok, Thailand
205.235.2909
🇿🇦Welkom, South Africa
205.235.3510 Cukurova Tip Fakultesi Balcali Hastanesi
🇹🇷Adana, Turkey
205.235.3508 Atatürk Gögüs Hastaliklari ve Gögüs Cerrahi
🇹🇷Ankara, Turkey
205.235.3504 Cevizli E5 Karayolu
🇹🇷Istanbul, Turkey
205.235.3509 Atatürk Üniversitesi Tip Fakultesi Aziziye
🇹🇷Erzurum, Turkey
205.235.3512 DokuzEylül Universitesi Tip Fakultesi Gögüs Hastaliklari ABD
🇹🇷Izmir, Turkey
205.235.3301 Boehringer Ingelheim Investigational Site
🇨🇳Taipei, Taiwan
205.235.3750 Boehringer Ingelheim Investigational Site
🇺🇸Bidderford, Maine, United States
205.235.0204 Boehringer Ingelheim Investigational Site
🇦🇺Cairns, Queensland, Australia
205.235.3302 Boehringer Ingelheim Investigational Site
🇨🇳Taipei, Taiwan
205.235.1404 Boehringer Ingelheim Investigational Site
🇭🇰Kowloon, Hong Kong
205.235.1403 Boehringer Ingelheim Investigational Site
🇭🇰Hong Kong, Hong Kong
205.235.1402 Boehringer Ingelheim Investigational Site
🇭🇰Kowloon, Hong Kong