A multicentre study in patients with localised prostate cancer for prediction of pathological stage of the radical prostatectomy and assessment of predictive factors of postoperative-recurrent.( Development of a Japanese Prostate Cancer Nomogram )

Not Applicable

• Conditions: Prostate Cancer

• Registration Number: JPRN-C000000333
• Lead Sponsor: Clinicopathological Research Group for Localized Prostate Cancer (CRPC)

Brief Summary

The Journal of Urology, Volume 180, Issue 3, Pages 904-910, (September 2008) Purpose: We validated the 2001 Partin tables and developed an original nomogram for Japanese patients using the 2005 International Society of Urological Pathology consensus on Gleason grading. Materials and Methods: Prostatectomy specimens from 1,188 Japanese men who underwent radical prostatectomy for clinically localized prostate cancer (cT1-2) between 1997 and 2005 were analyzed. Polychotomous logistic regression analysis was used to construct a nomogram to predict final pathological stage (organ confined disease, extraprostatic extension, seminal vesicle invasion and lymph node involvement) from 3 variables, including serum prostate specific antigen, clinical stage and biopsy Gleason score. The area under the ROC curve was used to compare the new nomogram with the Partin tables. Results: Preoperative serum prostate specific antigen and biopsy Gleason score were higher in the Japanese cohort than in the Partin cohort. The distribution of clinical and final pathological stages was similar in the 2 cohorts. The AUC for predicting organ confined disease was 0.699 and 0.717 for data applied to the Partin tables and to the new nomogram, respectively. The AUC for predicting lymph node involvement was 0.793 and 0.863, respectively. Conclusions: To our knowledge this is the first preoperative nomogram developed for clinically localized prostate cancer in Japanese patients. Although the new nomogram predicted the pathological stage of prostate cancer in Japanese patients more accurately than the Partin tables, it did not satisfactorily predict organ confined disease. However, other predictive variables, such as more detailed pathological features of biopsy specimens or magnetic resonance imaging, may further improve prediction accuracy.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2006-03-01
• Study Completion: 2008-06-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: Male
• Target Recruitment: 4000

Inclusion Criteria

Not provided

Exclusion Criteria

None

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1.Comparison of preoperative clinical data and histopathological findings of the biopsy specimen with histopathological findings of the radical prostatectomy specimen. 2.Prediction of PSA recurrence by the preoperative clinical data and histopathological findings of the biopsy specimen. 3.Prediction of PSA recurrence by histopathological findings of the radical prostatectomy specimen.