The Effects of Endurance and Strength Training in Subjects With Asthma
- Conditions
- Asthma
- Interventions
- Procedure: Standard Program + Endurance and Strength trainingProcedure: Standard Program
- Registration Number
- NCT04935125
- Lead Sponsor
- Istituti Clinici Scientifici Maugeri SpA
- Brief Summary
Emerging evidence suggests that regular exercise can complement medical treatment for asthma. Furthermore there are no specific recommendation on how plan exercise training. To the best of current knowledge, there isn't enough evidence of the effect of a strength training in subjects with asthma. Therefore the aim of this study is to evaluate the short and long term effects of a strength and endurance training compared with endurance training alone in subjects with asthma.
- Detailed Description
To the best of current knowledge, there isn't enough evidence of the effect of a strength training in subjects with asthma. Aim of the study is evaluate the short (after pulmonary rehabilitation) and long term (after 12 months) effects of a strength and endurance training compared with endurance training alone in improving quality of life and disease control in subjects with asthma of Global Initiative for Asthma (GINA) stage from 4 to 5.This is a prospective randomized control trial. Subjects with diagnosis of asthma according to the GINA guidelines admitted to a reference centre for inpatient pulmonary rehabilitation will be randomly assigned to study or control group.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 58
- Diagnosis of asthma step 4 to 5 under optimal medical treatment for at least 6 months according to GINA guideline
- Symptomatic despite being on treatment: Asthma Control Test (ACT) score ≥ 20 ≤24
- Able to perform and complete with studies procedures (FeNO, CPET, Six Minute Walking Test (6MWT), MVS.
- Diagnosis of Chronic Obstructive Pulmonary Disease (COPD) according to the Global initiative for Obstructive Lung Disease (GOLD) guidelines criteria
- Smokers or ex-smokers with pack/years ≥10
- Body Mass Index (BMI) ≥30
- Change in asthma medications in the last 30 days
- Cognitive impairment (Mini-Mental State Examination score <22)
- History of oncological, neurological, cardiovascular diseases, musculoskeletal impairment and/or medical diseases precluding exercise testing and pulmonary rehabilitation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Standard Program Standard Program + Endurance and Strength training twelve 30-minute daily sessions of supervised incremental exercise training over a period of 3 weeks. Standard Program Standard Program twelve 30-minute daily sessions of supervised incremental exercise training over a period of 3 weeks. Strength training Standard Program + Endurance and Strength training twelve 30-minute daily sessions of supervised incremental exercise training over a period of 3 weeks twelve 30-minute daily sessions of supervised peripheral limb muscle training, 2 set of 6-12 repetitions
- Primary Outcome Measures
Name Time Method asthma related Quality of Life 1 year Asthma Quality of Life Questionnaire (AQLQ). Range 0 (worst) - 7 (best)
- Secondary Outcome Measures
Name Time Method Asthma control 1 year Asthma Control Questionnaire (ACQ-6) Range 0 (best) - 6 (worst)
Aerobic capacity 1 year Maximum oxygen capacity(VO2max) assessed by Cardio Pulmonary Exercise Test (CPET)
Eosinophilic airway inflammation 1 year Fractional Exhaled Nitric Oxide (FeNO).
Quadriceps and biceps strength 1 year Maximal Voluntary isometric Strength (MVS).
Treatment satisfaction 1 year Global Perceived Effect (GPE) score 1 (best) - 7 (worst)
Numbers of exacerbations 1 year number of exacerbations in the last 12 months.
Trial Locations
- Locations (1)
Istituti Clinici Maugeri Pneumologia
🇮🇹Tradate, Lombardia, Italy