Comparison of the effect of anti-hypertensive treatment with verapamil and amlodipine on the coronary vasodilator reserve and the transmural distribution of myocardial blood flow in hypertensive patients with left ventricular hypertrophy
Not Applicable
Completed
- Conditions
- HypertensionCirculatory System
- Registration Number
- ISRCTN35563487
- Lead Sponsor
- Abbott (Germany)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
1. Blood pressure (measured after 5 minutes in the supine position) 160/100 mmHg based on the mean of 3 recordings within a 1 minute interval
2. Left ventricular septum thickness >=13 mm or left ventricular mass index (LVMI) >=130 g/m2 (men), >=100 g/m2 (women). The measurements will be recorded by echocardiography.
Exclusion Criteria
1. Women of childbearing age without adequate contraception
2. Any documented disease of any of the following systems will be a contraindication to entry into the study: respiratory, renal, digestive, nervous central or peripheral, musculoskeletal, haemolymphopoietic, immune, metabolism
3. Subjects with drug or alcohol addiction
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary objective of the study is to compare the Coronary Vasodilator Reserve corrected after treatment with verapamil, placebo and amlodipine in hypertensive subjects with left ventricular hypertrophy. With two treatments, two measurements and a within-subject control.
- Secondary Outcome Measures
Name Time Method Reduction of left ventricular mass