NCT03015090已完成不适用
Association Study Between CYP1A2 Gene Polymorphisms and Metabolism of Theophylline in Han and Uygur Patients With COPD
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- Plasma concentrations of theophylline
研究概览
简要总结
The aim of this study is to determine whether common CYP1A2 gene polymorphisms effect metabolism of theophylline in Han and Uygur Patients with chronic obstructive pulmonary disease patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged 18-75 years,Weight 40-80kg COPD patients, male or female; regularly visiting our hospital; taking a sustained-release preparation of theophylline continuously for at least 2 weeks
排除标准
- •Patients with renal or hepatic dysfunction; Patients with congestive heart failure; Patients with hypothyroidism or hyperthyroidism; Patients currently taking drugs likely to effect theophylline metabolism or who had taken such drugs in the preceding week; Patients with extreme obesity Patients with very severe Chronic Obstructive Pulmonary Disease(COPD)
研究组 & 干预措施
theophylline
Experimental
干预措施: Theophylline (Drug)
结局指标
主要结局
Plasma concentrations of theophylline
时间窗: one week
Blood samples will be taken after receiving oral theophylline
次要结局
未报告次要终点
研究者
XiaoGuang Zou
Professor of Pharmacy
Kashgar 1st People's Hospital
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Association Between CytochromeP4501A2 and CytochromeP4502E1 Gene Polymorphisms and Metabolism of TheophyllineChronic Obstructive Pulmonary DiseaseNCT02001935Zhujiang Hospital102
已完成
1 期
Caffeine and anaerobic exercise performance: an exploration of caffeine’s effects on performance in young men and the influence of genotype on the variation in responsesExercise performanceMusculoskeletal - Normal musculoskeletal and cartilage development and functionMetabolic and Endocrine - Normal metabolism and endocrine development and functionACTRN12619000885190Victoria University22
已完成
1 期
Pharmacokinetics of Tasimelteon Alone and in Combination With CYP1A2 Inhibitor, FluvoxamineHealthy VolunteersNCT01540500Vanda Pharmaceuticals24
已完成
不适用
Metabolism of Chlordiazepoxide in the Treatment of Alcohol Withdrawal SymptomsAlcohol WithdrawalNCT05563350University Hospital Bispebjerg and Frederiksberg26
已完成
不适用
Impact of CYP3A4*1G Polymorphism on Metabolism of Fentanyl in Chinese Patients Undergoing Lower Abdominal SurgeryPainSurgeryNCT01181492Huazhong University of Science and Technology176