Comparison of the efficacy of ephedrine versus norepinephrine in the treatment of hypotension occurring after induction of general anesthesia in patients with chronic renal failure: randomized double-blind pilot study

CHU Brugmann0 个研究点目标入组 60 人开始时间: 2022年8月18日最近更新: 2024年7月8日

适应症

试验速览

暂无简介。

•Age between 18 and 75 years old
•Signed informed consent
•Elective, non-cardiac surgery
•General anaesthesia
•Chronic renal failure with a GFR less than 45ml/min/m2 (stages below grade 3b and chronically on dialysis).
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 25
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 35

•Congestive heart failure with LVEF < 50%
•Moderate or severe cardiomyopathy or valvulopathy
•History of atrial or ventricular arrhythmia
•Taking drugs from the class of ACE inhibitors and sartans <24 hours before anesthesia
•Chronic treatment with central antihypertensives such as a2 agonists
•Chronic treatment with antidepressants of the following classes: selective norepinephrine reuptake inhibitors, tricyclic antidepressants, serotonin and norepinephrine reuptake inhibitors, norepinephrine and dopamine reuptake inhibitors, monoamine oxidase inhibitors.
•BMI <18.5kg/m2 or >35kg/m2
•ASA score = 4
•Pregnant women
•Allergy to a product used for anesthesia
•Prone position required during surgery.

发起方