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Clinical Trials/NCT05243485
NCT05243485
Completed
Not Applicable

Prehospital Triage of Patients With Suspected Non-ST-segment Elevation Acute Coronary Syndrome: the TRIAGE-ACS Study

Catharina Ziekenhuis Eindhoven1 site in 1 country1,071 target enrollmentApril 1, 2021

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
ACS
Sponsor
Catharina Ziekenhuis Eindhoven
Enrollment
1071
Locations
1
Primary Endpoint
Time from first medical contact to final invasive diagnostics and revascularization
Status
Completed
Last Updated
2 years ago

Overview

Brief Summary

With the Emergency Medical Services (EMS), no prehospital risk stratification and triage is performed for patients suspected of having an Non-ST-segment elevation Acute Coronary Syndrome (NSTE-ACS). While the latest ESC Guidelines recommend an early invasive strategy within 24 hours for all high risk NSTE-ACS patients and same-day transfer to a PCI (Percutaneous Coronary Intervention) center. With the potential emerging logistical problem surrounding this, prehospital risk stratification and triage can have great benefits in this population as well, especially in patients with a high risk of having an NSTE-ACS. The recently validated PreHEART score makes it possible to stratify patients in a low-risk and high-risk group for having a NSTE-ACS and gives the EMS the opportunity to make triage decisions in the prehospital setting. Patients with a high risk for having an NSTE-ACS are transferred directly to an PCI-center for further diagnostic work-up. Patients with a low risk for having NSTE-ACS and transferred to the ED of the nearest hospital without PCI facilities (non-PCI center) for further diagnostic work-up, resulting in an optimization of the regional care utilization.

This is the first study to focus on patients who are at a high risk of having an NSTE-ACS and to assess if whether prehospital triage using the PreHEART score is able to significantly reduce time to final invasive diagnostics and revascularization in patients in need of coronary revascularization.

Registry
clinicaltrials.gov
Start Date
April 1, 2021
End Date
December 1, 2023
Last Updated
2 years ago
Study Type
Observational
Sex
All

Investigators

Sponsor
Catharina Ziekenhuis Eindhoven
Responsible Party
Principal Investigator
Principal Investigator

Pieter-Jan Vlaar

Principal investigator

Catharina Ziekenhuis Eindhoven

Eligibility Criteria

Inclusion Criteria

  • Chest pain suspected for NSTE-ACS
  • Age ≥ 18 years
  • Intention to transfer patient to Emergency Department

Exclusion Criteria

  • ST-segment elevation Acute Coronary Syndrome
  • Post resuscitation patients
  • Hemodynamic instability defined as Killip Class IV
  • Suspected other life treating pathology
  • Pregnancy
  • No informed consent for data usage

Outcomes

Primary Outcomes

Time from first medical contact to final invasive diagnostics and revascularization

Time Frame: Time from first medical contact by EMS to final invasive diagnostics and revascularization, up to 60 days

Duration of time from first medical contact (in the EMS) to final invasive diagnostics and revascularization

Secondary Outcomes

  • Number of participants with ischemic complications(2 years)
  • Number of participants with safety endpoints during invasive diagnostics and/or revascularization(During hospitalization, up to 60 days)
  • Logistics during hospitalization(30 days)
  • Number of participants who suffer all cause death(1 and 2 years)
  • Number of participants with Major Adverse Cardiac Events(7 and 30 days)
  • Economic endpoints(During hospitalization, up to 60 days)

Study Sites (1)

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