The ACCEPT study
- Conditions
- CancerDiffuse large B-cell lymphoma
- Registration Number
- ISRCTN13626902
- Lead Sponsor
- niversity Hospital Southampton NHS Foundation Trust
- Brief Summary
2020 Protocol article in https://pubmed.ncbi.nlm.nih.gov/33093947/ protocol (added 26/10/2020)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 38
1. Histologically confirmed DLBCL, expressing CD20. Sufficient diagnostic material should be available to forward to a central laboratory for gene expression profiling and pathology review
2. Measurable disease of at least 15mm
3. Not previously treated for lymphoma and fit enough to receive combination chemoimmunotherapy with curative intent
4. Stage IAX (bulk defined as lymph node diameter >10cm) to stage IV disease and deemed to require a full course of chemotherapy. Patients with non-bulky IE disease are not eligible
5. ECOG performance status 0-2 or 3 if this is directly attributable to lymphoma
6. Adequate bone marrow function with platelets > 100x109/L; neutrophils > 1.0x109/L at study entry, unless lower figures are attributable to lymphoma
7. Measured or calculated creatinine clearance > 30mls/min, (calculated using the formula of Cockcroft and Gault [(140-Age) x Mass (kg)x(1.04 (for women)or 1.23 (for men))/Serum Creatinine (umolL)]
8. Serum bilirubin < 35µmol/L and transaminases < 2.5x upper limit of normal at time of study entry
9. Cardiac function sufficient to tolerate 300mg/m2 of doxorubicin. A pre-treatment echocardiogram or MUGA is required to establish baseline LVEF equal to or greater than 55%
10. No concurrent uncontrolled medical condition
11. Life expectancy > 3 months
12. Aged 16 years or above
13. Willing and able to participate in all required evaluations and procedures in this study protocol including swallowing capsules without difficulty
14. Ability to understand the purpose and risks of the study and provide signed and dated informed consent
1. Previous history of treated or untreated indolent lymphoma. However newly diagnosed patients with DLBCL who are found to also have small cell infiltration of the bone marrow or other diagnostic material (discordant lymphoma) will be eligible
2. Diagnosis of primary mediastinal lymphoma
3. Diagnosis of primary Central Nervous System lymphoma.
4. History of stroke or intracranial haemorrhage in preceding 6 months
5. History of bleeding diathesis (eg. haemophilia, von Willebrand disease)
6. Requires or receiving anticoagulation with warfarin or equivalent antagonists (eg. phenprocoumon) within 7 days of first dose of acalabrutinib. However patients using therapeutic low molecule weight heparin or low dose aspirin will be eligible
7. Prior exposure to a BCR inhibitor(eg. BtK inhibitors, phosphoinositide-3 kinase (PI3K), or SyK inhibitors) or BCL-2 inhibitor (eg. ABT-199)
8. Requires treatment with a strong cytochrome P450 3A4 (CYP3A4) inhibitor/inducer
9. Requires treatment with proton pump inhibitors (eg, omeprazole, esomeprazole, lansoprazole, dexlansoprazole, rabeprazole, or pantoprazole). Patients receiving proton pump inhibitors who switch to short-acting H2-receptor antagonists or antacids are eligible for enrolment into this study.
10. Uncontrolled systemic infection
11. Major surgery in the preceding 4 weeks of first dose of study drug. If a subject had major surgery, they must have recovered adequately from any toxicity and/or complications from the intervention before the first dose of study drug
12. Significant cardiovascular disease such as uncontrolled or symptomatic arrhythmias, congestive heart failure, or myocardial infarction within 6 months of screening, or any Class 3 or 4 cardiac disease as defined by the New York Heart Association Functional Classification, or corrected QT interval (QTc) > 480 msec at screening.
13. Serological positivity for Hepatitis B, C, or known HIV infection. As per standard of care, prior to initiation of immunochemotherapy, the results of hepatitis serology should be known prior to commencement of therapy. - Positive test results for chronic HBV infection (defined as positive HBsAg serology) will not be eligible. Patients with occult or prior HBV infection (defined as negative HBsAg and positive total HBcAb) will not be eligible. Patients who have protective titres of hepatitis B surface antibody (HBsAb) after vaccination will be eligible. - Positive test results for hepatitis C virus (HCV) antibody serology will not be eligible.
14. Women who are sexually active and can bear children must agree to use highly effective forms of contraception during the study and for 90 days after the last dose of acalabrutinib. Highly effective forms of contraception are defined in Section 4.7 14. Breastfeeding or pregnant
15. Men who are sexually active and can potentially father children must agree to use highly effective forms of contraception during the study and for 90 days after the last dose of acalabrutinib. Highly effective forms of contraception are defined in Section 4.7
16. Men must agree to refrain from sperm donation during the study and for 90 days after the last dose of study drug.
17. Serious medical or psychiatric illness likely to affect participation or that may compromise the ability to give informed consent
18. Prior malignancy (other than DLBCL), except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, or other cancer from which the
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Phase I<br>1. Dose limiting toxicity of acalabrutinib combined to R-CHOP is measured using a physical examination, vital signs, laboratory tests FBC, renal and liver function, ECOG, at baseline and for all cycles and repeated for specific cycles day 8 and day 15 for cycle 2 and day 8 at cycle 4.*<br><br>Phase II<br>1. Overall response rate of the combination acalabrutinib and R-CHOP is measured using PET/CT at baseline, cycle 7, month 12, month 24 End of treatment using the Lugano classification for NHL<br>2. Safety of the combination acalabrutinib and R-CHOP is measured using a physical examination, vital signs, laboratory tests FBC, renal and liver function, ECOG at baseline and for all cycles and repeated for specific cycles day 8 and day 15 for cycle 2 and day 8 at cycle 4.*<br><br>*There will be 8 cycles if chemotheraphy administered. Cycle 1-6 will be 21 days and Cycle 7 and 8 will be 28 days Aclabrutinib will be administered from cycle 2 and will be taken from cycle 2 to cycle 7.
- Secondary Outcome Measures
Name Time Method 1. Pharmacokinetic of acalabrutinib, AUC, Cmax, Tmax, half-life T1/2 and other PK parameter is measured using serum concentration taken at cycle 2, Day 1, day 8 and day 15 half hour before the administration of acalabrutinib. Once acalabrutinib is administered serum concentration will be taken 45 mins, 1 hour, 2 hours and 8 hours and once again before acalabrutinib is administered at cycle 3<br>2. Overall response rate of the combination acalabrutinib and R-CHOP according to cell of origin is measured using of BCR DNA extracted from tumour material will be used to perform mutation detection on BCR pathway (eg Btk, PI3K, CD79b). Genetic abnormalities of BCR pathway will be correlated with clinical outcomes and the expression pathway target genes at baseline<br>3. Two years progression-free survival rate is measured using CT at 24 months<br>4. Two years overall survival rate is measured using CT at 24 months