Hemodynamic Repercussions of Ventilator Hyperinflation Using Volume-controlled Ventilation: a Randomized Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Respiratory Failure
- Sponsor
- Centro Universitário Augusto Motta
- Enrollment
- 17
- Locations
- 1
- Primary Endpoint
- Change in Cardiac Output
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Ventilator hyperinflation (VHI) has been shown to be effective in improving respiratory mechanics, secretion removal, and gas exchange in mechanically ventilated patients; however, the literature is scarce concerning its safety and adverse effects. Thus, the aim of this study is to compare the hemodynamic repercussions of VHI in volume-controlled mode. In a randomized, controlled and crossover design, 24 mechanically ventilated patients will undergo 2 modes of ventilator hyperinflation (with and without an inspiratory pause) and a control intervention. Cardiac output, cardiac index, mean arterial pressure, pulmonary vascular resistance, systolic volume and other hemodynamic variables will be recorded during the interventions.
Detailed Description
Background: ventilator hyperinflation (VHI) has been shown to be effective in improving respiratory mechanics, secretion removal, and gas exchange in mechanically ventilated patients; however, the literature is scarce concerning its safety and adverse effects. Thus, the aim of this study is to compare the hemodynamic repercussions of VHI in volume-controlled mode. Methods: in a randomized, controlled and crossover design, 24 mechanically ventilated patients will undergo 2 modes of ventilator hyperinflation (with and without an inspiratory pause of 2 seconds) and a control intervention. For the VHI interventions, the inspiratory flow will be set at 20 Lpm, and tidal volume will be increased until a peak pressure of 40cmH2O is achieved. During the control intervention, the patients will remain in volume-control ventilation with an inspiratory flow = 60Lpm and tidal volume = 6mL/IBW. The interval between interventions (washout) will be of 10 minutes or more, according to the time needed to recover the cardiac index to baseline values (maximum difference of 10%). Cardiac output, cardiac index, mean arterial pressure, pulmonary vascular resistance, systolic volume and other hemodynamic variables will be recorded during the interventions by using impedance cardiography.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients under mechanical ventilation for more than 48h
Exclusion Criteria
- •mucus hypersecretion (defined as the need for suctioning \< 2-h intervals),
- •absence of respiratory drive,
- •atelectasis,
- •severe bronchospasm,
- •positive end expiratory pressure \> 10cmH2O,
- •PaO2-FiO2 relationship \< 150,
- •mean arterial pressure \< 60mmHg,
- •inotrope requirement equivalent to \>15 ml/h total of adrenaline and noradrenalin,
- •intracranial pressure \> 20mmHg
Outcomes
Primary Outcomes
Change in Cardiac Output
Time Frame: Baseline (before) and 10 minutes after the onset of VHI modesBasel
Estimation of cardiac output variation using thoracic bioimpedance
Secondary Outcomes
- Change in Systolic Volume II(Baseline (before) and 5 minutes after the end of VHI modes)
- Change in Vascular pulmonary resistance(Baseline (before) and 10 minutes after the onset of VHI modes)
- Change in Mean Arterial Pressure(Baseline (before) and 10 minutes after the onset of VHI modes)
- Change in Cardiac Index II(Baseline (before) and 5 minutes after the end of VHI modes)
- Change in Vascular pulmonary resistance II(Baseline (before) and 5 minutes after the end of VHI modes)
- Change in Mean Arterial Pressure II(Baseline (before) and 5 minutes after the end of VHI modes)
- Change in Cardiac Index(Baseline (before) and 10 minutes after the onset of VHI modes)
- Change in Systolic Volume(Baseline (before) and 10 minutes after the onset of VHI modes)
- Change in Cardiac Output II(Baseline (before) and 5 minutes after the end of VHI modes)