Comparative study of hemodynamic changes with dexmedetomidine versus magnesium sulphate as adjuncts during anaesthesia in laparoscopic surgeries – a double blinded randomised study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- hemodynamic response of two drugs during intubation and CO2 insuffulation
研究概览
简要总结
• All patients undergoing laparoscopic surgeries will undergopre-anaesthetic assessment and informed and written consent will be taken.
• The drugs to be given - group D: dexmedetomidine loading 1 mcg/kg in 100mL normal saline over 15 min; and Group M: magnesium sulfate 50mg/kg in 100 mLover 15 min, prior to intubation.
• Baseline data systolic blood pressure (SBP), diastolic blood pressure(DBP), mean arterial blood pressure (MAP), and heart rate (HR) werenoninvasively monitored
• SBP,DBP, MAP and HR to be monitored at every 10 min intervals throughout thesurgery.
Following extubation, patientswere maintained on supplemental O2 and transferred to recovery room.
• Intubationresponse : immediately after intubation (T0), 1 min after intubation (T1),3mins after inubation (T3), 5mins after intubation (T5)
• CO2 insufflation :1mins after insufflation (C1), 3mins afterinsufflation(C3), 5mins after insufflation (C5)
• Extubation response : immediately after extubation (E0), 1min afterextubation (E1), 5mins after extubation (E5)
• The degree of sedation was assessed at the end of surgery after thepatient is received in the recovery room using Brussels sedation scale
研究设计
- 研究类型
- Interventional
- 分配方式
- Random Number Table
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •asa grade 1 and 2 elective and emergency laparoscopic surgeries.
排除标准
- •morbid obesity pregnant woman renal or hepatic dysfunction cardiovascular insufficiency.
结局指标
主要结局
hemodynamic response of two drugs during intubation and CO2 insuffulation
时间窗: At baseline. | Intubation response : Immediately after intubation(T0) | 1 mintue after intubation (T1) | 3 mintues after intubation (T3) | 5 minutes after intubation (T5) | Before insuffulation | 1 minute after CO2 insuffulation (C1) | 3 minutes after CO2 insuffulation (C3) | 5 minutes after CO2 insuffulation (C5) | Every 10 minute intraoperative monitoring
次要结局
- hemodynamic response of two drugs during extubation and postoperative sedation score of patient(5 minutes post extubation)