Comparing the effects of two drugs, Dexmedetomidine and Magnesium Sulphate, on the Blood Pressure and Pukse rate changes that occur during Laparoscopic surgeries

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2021/11/038123
• Lead Sponsor: Chettinad Hospital And Research Institute

Brief Summary

•      All patients undergoing laparoscopic surgeries will undergopre-anaesthetic assessment and informed and written consent will be taken.

•      The drugs to be given - group D: dexmedetomidine loading 1 mcg/kg in 100mL normal saline over 15 min; and Group M: magnesium sulfate 50mg/kg in 100 mLover 15 min, prior to intubation.

•      Baseline data systolic blood pressure (SBP), diastolic blood pressure(DBP), mean arterial blood pressure (MAP), and heart rate (HR) werenoninvasively monitored

•      SBP,DBP, MAP and HR to be monitored at every 10 min intervals throughout thesurgery.

Following extubation, patientswere maintained on supplemental O2 and transferred to recovery room.

•      Intubationresponse : immediately after intubation (T0), 1 min after intubation (T1),3mins after inubation (T3), 5mins after intubation (T5)

•      CO2 insufflation :1mins after insufflation (C1), 3mins afterinsufflation(C3), 5mins after insufflation (C5)

•      Extubation response : immediately after extubation (E0), 1min afterextubation (E1), 5mins after extubation (E5)

•      The degree of sedation was assessed at the end of surgery after thepatient is received in the recovery room using Brussels sedation scale

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2021-11-18
• Study Start: 2021-11-21

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

asa grade 1 and 2 elective and emergency laparoscopic surgeries.

Exclusion Criteria

morbid obesity pregnant woman renal or hepatic dysfunction cardiovascular insufficiency.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
hemodynamic response of two drugs during intubation and CO2 insuffulation	At baseline. | Intubation response : Immediately after intubation(T0) | 1 mintue after intubation (T1) | 3 mintues after intubation (T3) | 5 minutes after intubation (T5) | Before insuffulation | 1 minute after CO2 insuffulation (C1) | 3 minutes after CO2 insuffulation (C3) | 5 minutes after CO2 insuffulation (C5) | Every 10 minute intraoperative monitoring

Secondary Outcome Measures

Name	Time	Method
hemodynamic response of two drugs during extubation and postoperative sedation score of patient	5 minutes post extubation

Trial Locations

Locations (1)

Chettinad Hospital and Research Institute; 🇮🇳 Kancheepuram, TAMIL NADU, India

Chettinad Hospital and Research Institute

🇮🇳Kancheepuram, TAMIL NADU, India

dr BI Nirupama

Principal investigator

9566083030

b.i.nirupama@gmail.com