Assessment of the prognostic significance of the leg positive pressure stress echocardiography for patients with aortic valve stenosis
- Conditions
- Patients with aortic valve stenosis
- Registration Number
- JPRN-UMIN000022391
- Lead Sponsor
- Division of cardiology, Kobe university hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 80
Not provided
1) Patients with significant hypotension (<90/50mmHg) or uncontrolled hypertension (>170/90mmHg). 2) Patients with acute illness within 3 months. 3) Patients with NYHA 4 heart failure. 4) Patients with unstable angina pectoris or more than 75% (AHA craiteria)coronary artery stenosis. 5) patients with more than moderate valvular regurgitation. 6) Patients with severe hepatic diseases including fulminant hepatitis, liver cirrhosis, or hepatic tumor. 7) Patients with severe renal diseased or those with hemodialysis. 8) Patients who experienced malignancy within 5 years. 9) Pregnant women. 10) Patients with venous thrombosis or the history of venous thrombosis. 11) Patients with leg trauma and dermopathy or the history of those diseases.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Combined endpoint of admission due to heart failure, death from heart failure, sudden cardiac death, and fatal ventricular arrhythmias.
- Secondary Outcome Measures
Name Time Method 1) Change in NYHA functional class from baseline. 2) Changes in left ventricular ejection fraction, left ventricular end-diastolic, and end-systolic volume from baseline. 3) changes in contractile reserve and diastorlic reserve from baseline. 4) Changes in right ventricular and left atrial function from baseline using speckle-tracking echocardiography.